Sleep and its regulation: An emerging pathogenic and treatment frontier in Alzheimer's disease

BA Kent, HH Feldman, HB Nygaard - Progress in neurobiology, 2021 - Elsevier
A majority of patients with Alzheimers disease (AD) experience some form of sleep disruption,
including nocturnal sleep fragmentation, increased daytime napping, decreased slow-…

New frontiers in the prevention, diagnosis, and treatment of Alzheimer's disease

L Guzman-Martinez, C Calfío, GA Farias… - … Alzheimer's disease, 2021 - content.iospress.com
One of the major puzzles in medical research and public health systems worldwide is
Alzheimers disease (AD), reaching nowadays a prevalence near 50 million people. This is a …

APOE: The New Frontier in the Development of a Therapeutic Target towards Precision Medicine in Late-Onset Alzheimer's

A Yang, B Kantor, O Chiba-Falek - International journal of molecular …, 2021 - mdpi.com
Alzheimers disease (LOAD). An exploration of APOE as a new therapeutic culprit has
produced some very encouraging results, proving that the protein holds promise in the context of …

Alzheimer's disease: an update and insights into pathophysiology

MB Abubakar, KO Sanusi, A Ugusman… - Frontiers in aging …, 2022 - frontiersin.org
Alzheimers disease (AD) is a progressive brain disease that is attributed by the Alzheimer
… Depending on the stage of the disease, it is characterized by factors that progress to hinder …

New insights into the pathogenesis of Alzheimer's disease

L Fan, C Mao, X Hu, S Zhang, Z Yang, Z Hu… - Frontiers in …, 2020 - frontiersin.org
Alzheimer's disease (AD), a common neurodegenerative disease in the elderly and the most
prevalent cause of dementia, is characterized by progressive cognitive impairment. The …

Research hotspots and frontiers of stem cells for Alzheimer's disease

L Xie, S Cui, N Guo, A Li, J Zhang - Chinese Journal of Tissue …, 2025 - cjter.com
… Stem cell therapy for Alzheimers disease has broad prospects. … of stem cell therapy for
Alzheimers disease, solve possible clinical … of stem cells in the treatment of Alzheimers disease. …

[HTML][HTML] Mitochondrial dysfunction and Alzheimer's disease: Role of microglia

I Agrawal, S Jha - Frontiers in aging neuroscience, 2020 - frontiersin.org
In 1907 Alois Alzheimer observed, as he quoted, development of “numerous fibers” and “adipose
saccules” in the brain of his diseased patient Auguste Deter. The neurodegenerative …

A path toward precision medicine for neuroinflammatory mechanisms in Alzheimer's disease

…, M Watling, BP Imbimbo, A Vergallo, S Lista - Frontiers in …, 2020 - frontiersin.org
Neuroinflammation commences decades before Alzheimer's disease (AD) clinical onset and
represents one of the earliest pathomechanistic alterations throughout the AD continuum. …

The important interface between apolipoprotein E and neuroinflammation in Alzheimer's disease

CM Kloske, DM Wilcock - Frontiers in immunology, 2020 - frontiersin.org
Alzheimers disease (AD) is the most prevalent form of neurodegenerative disease, … mechanisms
and the influence neuroinflammation has on disease progression. The vast majority of …

The impact of systemic inflammation on Alzheimer's disease pathology

J Xie, L Van Hoecke, RE Vandenbroucke - Frontiers in immunology, 2022 - frontiersin.org
Alzheimers disease (AD) is a devastating age-related neurodegenerative disorder with an
alarming increasing prevalence. Except for the recently FDA-approved Aducanumab of which …