… with HIV-1 CA provides additional insights for rational drug … high conservation in functional
regions between HIV-1 … , indicating an early stage effect. Ebselen also inhibits reverse …

… and functional roles of the HIV-1 Gag domains in virion integrity, functionality and infectivity.
… This differential effect may suggest the role of p9 in proviral integration as opposed to p15 …

… cleave the progenitors of the Gag and Gag-Pol polymers to produce … shift that diminished
the saquinavir effect without altering the … may function as a potential HIV-1 therapeutic agent by …

… completely avoidable, rational drug design can and should … the discovery of HIV-1 protease
inhibitor tipranavir, HIV-1 … considerations into drug design to improve potency and avoid …

… the Gag. In this study, LPV/r-resistance-associated mutations in Gag, PR, and Env were
characterized in HIV-1 … or causal meaning but may indicate a multivariable effect in the network. …

… structural and functional proteins in the gag-pol and gag polypeptides. (b) … drug discovery
against HIV PR was primarily due to a detailed understanding of the structural and functional …

… The development of new drugs designed to disrupt the viral … This review will focus on
illustrating the structure and function … truncation, and FIP1C depletion had no effect on the level of …

… HIV-1 RT mutation rates and biases on its own Gag, protease… functional sites in the background
mutations rates for Gag, … , hypothesized to be for the conservation of protein functions [35,…

… of HIV-1 mRNA maintains the stoichiometry of Gag to Gag-Pol … IN multimerization, the
consequences of which inhibit IN-… expanded the multimodal functionality of IN in HIV-1 replication. …

… With high sequence conservation, the HIV-1 capsid (CA) … Interprotomeric CA interactions
are critical for function, and … residues, the induced-fit effect should be followed to achieve a …