Quantifying mediation between omics layers and complex traits

MC Sadler, C Auwerx, E Porcu, Z Kutalik - bioRxiv, 2021 - biorxiv.org
… ), but not in a significant change in MP ( Embedded Image … our findings and confirming the
role of PDIA5 in thrombopoiesis… We examined regulatory effects of DNAm on gene expression

Genetic Studies Highlight the Role of TET2 and INO80 in DNA Damage Response and Kidney Disease Pathogenesis

X Liang, H Liu, H Hu, J Zhou, A Abedini, AS Navarro… - bioRxiv, 2024 - biorxiv.org
… In addition, examining changes in gene expression and regulation at a single-cell level, … ,
our unbiased gene expression and experimental analyses underscored the critical role of TET2 …

Kidney disease genetic risk variants alter lysosomal beta-mannosidase (MANBA) expression and disease severity

X Gu, H Yang, X Sheng, YA Ko, C Qiu, J Park… - Science translational …, 2021 - science.org
… and kidney function (in GWAS) and the genotype and gene expression in a … The genotype-gene
expression association of the top GWAS … Next, we analyzed gene expression changes in …

Plant gene expression control using genome-and epigenome-editing technologies

GS Miglani, A Kaur, L Kaur - Journal of Crop Improvement, 2020 - Taylor & Francis
… ) play an important role in gene expression control. sncRNAs are … Such changes in gene
expression do not involve changes in … of gene expression and genetic variation driven by DNA …

Genome-wide association studies identify the role of caspase-9 in kidney disease

T Doke, S Huang, C Qiu, X Sheng, M Seasock… - Science …, 2021 - science.org
… We next analyzed changes in injury setting, such as induced … between kidney function and
gene expression in tubuli and … traits (kidney function and gene expression) are associated, …

Mining genetic diversity for tomorrow's agriculture

YM Hsu - 2022 - theses.hal.science
changes including activated/deactivated gene expression, … the fused transcript with TEs
and genes, suggesting that such novel TE … This process plays a key role in the maintenance of …

Bioinformatic Analysis of SNVS of the SPP1 Gene and the Role of Testicular Disease in Systemic Lupus Erythematosus

A Rivera-Cameras, AV Ruiz-Ramírez… - 2022 - researchsquare.com
gene expression was analyzed with a focus on testicular tissue, as well as the participation
of in ammation and INF production, which could be playing a key role … see the changes in the …

Association between MANBA Gene Variants and Chronic Kidney Disease in a Korean Population

HR Kim, HS Jin, YB Eom - Journal of Clinical Medicine, 2021 - mdpi.com
… The MANBA gene variants showed significantfunction through an integrative analysis of
eQTL and CKD-related GWAS results. Moreover, this study confirmed MANBA gene expression

Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis

M Vujkovic, JM Keaton, JA Lynch, DR Miller, J Zhou… - … genetics, 2020 - nature.com
… T2D associations with genetically predicted gene expression in 687 novel genes; of these,
54 … tubule, where it plays an important role in kidney and urine function. A large-scale study in …

A genetically supported drug repurposing pipeline for diabetes treatment using electronic health records

MM Shuey, KM Lee, J Keaton, NK Khankari… - …, 2023 - thelancet.com
Genetic-variation-driven gene-expression changes highlight genes with important functions
… T2D risk per standard deviation change in gene expression. Furthermore, MR Egger …