Structural brain imaging studies offer clues about the effects of the shared genetic etiology among neuropsychiatric disorders

NV Radonjić, JL Hess, P Rovira, O Andreassen… - Molecular …, 2021 - nature.com
… among neuropsychiatric disorders and suggest that these … The genetic overlap across
disorders may partly explain why … low genetic correlation between neurological and psychiatric …

Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders: evidence through univariate and multivariate mega-analysis …

N Opel, A Thalamuthu, Y Milaneschi, D Grotegerd… - Molecular …, 2021 - nature.com
… Our findings suggest a neurobiological interaction between … have reported overlapping
brain structural abnormalities in … Similar to previous reports of accurate individual brain age

Multimodal imaging improves brain age prediction and reveals distinct abnormalities in patients with psychiatric and neurological disorders

J Rokicki, T Wolfers, W Nordhøy, N Tesli… - Human brain …, 2021 - Wiley Online Library
indicate that multidimensional neuroimaging of patients may provide a brain-based mapping
of overlapping … unique and additive contribution of genetic and environmental variables on …

MRI signatures of brain age and disease over the lifespan based on a deep brain network and 14 468 individuals worldwide

VM Bashyam, G Erus, J Doshi, M Habes, IM Nasrallah… - Brain, 2020 - academic.oup.com
… fit brain ageing models may provide brain age estimates that are … -fitting brain age models
naturally produce brain-age estimates … Our results indicate that moderately accurate brain age

Genetic variants associated with longitudinal changes in brain structure across the lifespan

RM Brouwer, M Klein, KL Grasby, HG Schnack… - Nature …, 2022 - nature.com
… To obtain the best experience, we recommend you use a more up to date browser (or turn
off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we …

Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes

…, Alzheimer's Disease Neuroimaging Initiative… - Molecular …, 2020 - nature.com
… experience, we recommend you use a … intracranial volume (ICV). In addition, utilizing
summary statistics from previous large-scale GWAS, we sought to characterize the genetic overlap

Cross-disorder analysis of brain structural abnormalities in six major psychiatric disorders: a secondary analysis of mega-and meta-analytical findings from the …

N Opel, J Goltermann, M Hermesdorf, K Berger… - Biological …, 2020 - Elsevier
… Therefore, we investigated the overlap between shared brain … Our findings thus suggest the
presence of a shared … differences in genetic variants across psychiatric disorders might thus …

Genetic analysis of the human microglial transcriptome across brain regions, aging and disease pathologies

KP Lopes, GJL Snijders, J Humphrey, A Allan… - … genetics, 2022 - nature.com
… to prioritize genes and variants that influence neurological disease … We overlapped the
region-specific genes with gene sets … , our results indicate that the microglial phenotype ages in a …

Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group

LKM Han, R Dinga, T Hahn, CRK Ching, LT Eyler… - Molecular …, 2021 - nature.com
… Substantial within-group variance and overlap between … 26], we estimated brain age
models separately for males and … that brain morphology is under control of distinct genetic and …

Mapping brain asymmetry in health and disease through the ENIGMA consortium

XZ Kong, MC Postema, T Guadalupe… - Human brain …, 2022 - Wiley Online Library
shared genetic contributions to brain asymmetry and … genetic overlap between these
asymmetries and cognitive or psychiatric … In relation to disorders, for example, our findings indicate