… We performed genetic association analysis of 287 K imputed SNPs in dataset 1. More
specifically, after sample filtering, a total of 8,490 individuals (4,662 cases with an age ≥90 and …

… existing genome-wide association summary statistics for … suggest the genetic components
of both human lifespan (ie the … -analysis to identify genetic variants related to healthy ageing. …

… genetic component to the sum of genetic and other (termed ‘environmental’) factors, and is
specific to each studied … estimates for human longevity from twin studies range from 20% to 30…

… genome-wide significant loci, of which 113 are novel, from genome-wide association study
(GWAS) meta-analyses … We find evidence for shared genetic loci associated with the Horvath …

… Understanding the genetic determinants and biological mechanisms … We performed a
genome-wide association study (GWAS) meta-analysis … 2.3 Candidate gene association analysis …

… the fact that longevity is genetically related to health, fertility and … genes for longevity detected
in the present study, 63 genes had … kept for association analysis on each longevity trait in …

… In the study of the genetics of human longevity, there are to … of extreme longevity as a paradigm
of healthy aging. A … (A) Manhattan plot for all the SNPs tested for the association analysis …

… and aging, we analyzed age-related expression and methylation profiles of genes associated
with SNPs identified in our study (… Using tissue-specific eQTL-gene associations, we first …

… on a large human genomic dataset generated by the Gene-Tissue … survey of tissue-specific
aging mechanisms and we showed that it could recapitulate multiple well-established aging …

… While human lifespan (ie the number of years alive) has increased by ~3.5 years per … of
years spent in good health) has not increased to the same extent. In 2015, people lived 5 years …