Alzheimer's disease-associated complement gene variants influence plasma complement protein levels

A Veteleanu, J Stevenson-Hoare, S Keat… - Journal of …, 2023 - Springer
… in biomarker and genome-wide association studies (GWAS). … regulators clusterin (CLU)
and complement receptor 1 (CR1), … Disorders and Stroke and the Alzheimer's disease and …

[PDF][PDF] Polymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer's

LH Chen, PYP Kao, YH Fan, DTY Ho, CSY Chan… - academia.edu
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's
disease. Nat … polymorphism is associated with Alzheimer's disease in Chinese patients. …

The impact of complement genes on the risk of late-onset Alzheimer's disease

SM Carpanini, JC Harwood, E Baker, M Torvell… - Genes, 2021 - mdpi.com
… large genome-wide association studies (GWAS) have identified … We confirmed associations
of CLU and CR1 genes with … four consortia: the Alzheimer Disease Genetics Consortium (…

The combined risk effect among BIN1, CLU, and APOE genes in Alzheimer's disease

LR Santos, JFF Almeida, LHS Pimassoni… - … and Molecular Biology, 2020 - SciELO Brasil
… ) Genome-wide association study identifies variants at CLU and PICALM associated with
Alzheimer’s disease, … and CR1 associated with Alzheimer’s disease. Nat Genet 41:1094–1099.; …

[PDF][PDF] Investigation of genome-wide association SNPs and Alzheimer's disease

MN Mikhail, AY Sayed, MS Mabrouk… - American Journal of …, 2020 - scholar.cu.edu.eg
… of genome-wide association study single nucleotide polymorphisms (SNPs) in Alzheimer’s
disease (… in the APOE ε4, CD33, CR1, BIN1, EPHA1 PICALM, NM8, CLU, CD2AP and SORL1 …

[HTML][HTML] … of cognitive performance and polymorphisms of SORL1, PVRL2, CR1, TOMM40, APOE, PICALM, GWAS_14q, CLU, and BIN1 in patients with mild cognitive …

F Cruz-Sanabria, K Bonilla-Vargas, K Estrada… - Neurología (English …, 2021 - Elsevier
Alzheimer disease, after APOE, 30 and has been associatedCR1 rs6656401 GG genotype
is reported to be associated … both in patients with late-onset Alzheimer disease and in …

Prediction of Alzheimer's disease using multi-variants from a Chinese genome-wide association study

L Jia, F Li, C Wei, M Zhu, Q Qu, W Qin, Y Tang, L Shen… - Brain, 2021 - academic.oup.com
identified variants to disease pathogenesis. In conclusion, this is the first study to validate
genome-wide association study-… for evaluating the risk of Alzheimer’s disease onset in a large …

Genomics of Alzheimer's disease implicates the innate and adaptive immune systems

Y Li, SM Laws, LA Miles, JS Wiley, X Huang… - Cellular and Molecular …, 2021 - Springer
… AD-associated susceptibility loci have been identified by genome-wide association studies
(… Regarding the established AD susceptibility loci, the association signals in CR1, CLU, and …

[HTML][HTML] Alzheimer's disease related single nucleotide polymorphisms and correlation with intracerebral hemorrhage incidence

RP Sawyer, SL Demel, ME Comeau, M Marion… - Medicine, 2022 - journals.lww.com
… and haplotypes were associated with ICH utilizing genome-wide association study data from
2 independent studies (genetic … We identified that variation within CR1 and CLU, previously …

Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers

…, L Tárraga, S Teipel, GR@ ACE study group… - Acta …, 2022 - Springer
… , novel associations with two other well-established AD risk loci were observed; CR1 was
shown a locus for Aβ42 and BIN1 for pTau. GMNC and C16orf95 were further identified as loci …