How understudied populations have contributed to our understanding of Alzheimer's disease genetics

N Dehghani, J Bras, R Guerreiro - Brain, 2021 - academic.oup.com
… The majority of genome-wide association studies have been … in CLU is only associated with
Alzheimer’s disease in NHWs (OR … Data from this population also suggest that both CR1 and …

Three-dimensional chromatin architecture datasets for aging and Alzheimer's disease

G Meng, H Xu, D Lu, S Li, Z Zhao, H Li, W Zhang - Scientific Data, 2023 - nature.com
Genome-wide association studies have identified many risk … system process (TNF, IL8, CR1,
CLU, CCR2, PICALM, and … gene, among which 37 SNPs were linked to CR1 by 67 eQTLs in …

Associations of risk genes with onset age and plasma biomarkers of Alzheimer's disease: a large case–control study in mainland China

B Jiao, X Xiao, Z Yuan, L Guo, X Liao, Y Zhou… - …, 2022 - nature.com
… have been identified by genome-wide association studies (… two GWAS studies in AD
demonstrated that CLU, CR1, and … , another GWAS identified that BIN1 was associated with AD […

[HTML][HTML] Genetics of Alzheimer's disease: where we are, and where we are going

C Bellenguez, B Grenier-Boley, JC Lambert - Current opinion in …, 2020 - Elsevier
… been known that rare forms of Alzheimer's disease (AD) are fully … In particular, genome-wide
association studies (GWASs) … of three new genetic risk factors: CLU, CR1 and PICALM [8,9]. …

GWAS-Top polymorphisms associated with late-onset Alzheimer disease in Brazil: pointing out possible new culprits among non-coding RNAs

GC Kretzschmar, NM Alencar, SSL da Silva… - Frontiers in Molecular …, 2021 - frontiersin.org
genome-wide association studies (GWAS) have been carried out with late-onset Alzheimer’s
disease (… Different polymorphisms were associated, but several of them without a functional …

Sharing of genetic Association signals by age-related macular degeneration and Alzheimer's disease at multiple levels

H Tan, M Lv, X Tan, G Su, R Chang, P Yang - Molecular Neurobiology, 2020 - Springer
… was conducted to investigate the genetic factors shared by both diseases. We analyzed
genome-wide association studies’ summary statistics from both diseases using a new platform …

[HTML][HTML] Multiomics integrative analysis identifies APOE allele-specific blood biomarkers associated to Alzheimer's disease etiopathogenesis

…, Alzheimer's Disease Neuroimaging Initiative … - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
… Combining genome-wide association studies (GWAS) with … for APOE, BIN1, CLU and
PICALM in the APOE4 stratum. We … , with CR1 and ATP5F1 as RRA candidates in both strata. …

Genomics of Alzheimer's disease

MP van de Weijer, IE Jansen, AHA Verboven… - Personalized …, 2020 - Elsevier
… Since the advent of genome-wide association studies, there … genomics research for AD since
the advent of genome-wideidentified in previous GWA studies (ABCA7, BIN1, CLU, CR1, …

An integrated genome and phenome-wide association study approach to understanding Alzheimer's disease predisposition

AS Khaire, CE Wimberly, EC Semmes, JH Hurst… - Neurobiology of …, 2022 - Elsevier
Genome-wide association studies (GWAS) have identified common single nucleotide …
late-onset Alzheimer's disease (LOAD) risk. To identify additional LOAD-associated variants and …

A scalable Bayesian functional GWAS method accounting for multivariate quantitative functional annotations with applications for studying Alzheimer disease

J Chen, L Wang, PL De Jager, DA Bennett… - Human Genetics and …, 2022 - cell.com
genome-wide association studies (GWASs) to fine-map and prioritize potential causal variants
… the computation burden of modeling genome-wide variants. To overcome these limitations…