… alterations, focusing on DNA methylation and histone modifications in the development and
… of novel epigenetic biomarkers of cancer incidence risk, to predict drug response or poor …

… -K27ac sites and recurrence of H3K27ac … chromatin state predictions in each condition
based on relative enrichment levels of histone modifications, transcription factors and chromatin …

… describing recurrent epigenetic alterations in prostate cancer … define chromatin structure
as histone modifications and … Low levels of H3K9me2 have been shown to predict poor …

… (PCa) is the most common malignancy found in males worldwide. Although it is mostly … the
study, we used cancer-specific death or biochemical recurrence as the outcomes to represent …

… Three distinct m6A modification patterns were identified … was found among these groups in
recurrence-free survival (RFS) … through histone methylation and DNA methylation significantly …

… However, the global relationship between epigenetic alterations… Here, we conducted a
systematic analysis to identify global … Here, we describe methylation regulation patterns in PCa at …

… Global analysis of histone modification in PCa specimens … with the clinical outcome and
biochemical recurrence of the … to predict PCa patients with higher risk of developing lethal …

… We reasoned that recurrent intergenic HMRs would be … changes, such as histone modification
or DNA methylation 55,56 … for which methylation predicted expression independently from …

… and we hypothesize a methylation signature predicting … recurrence. Group 2 incorporated
20 patients with Gleason score 6/7a … histone methylation as a common denominator of prostate …

… levels of histone modifications may be used to predicting the early and late recurrence of …
less than 30% H3K9AC staining; however, in prostate cancer, more than 50% of the samples …