… inaccessible sites. Still, its therapeutic role is difficult to study as EPC could not be the only
cell type … , and manipulate exerkines to harness their full power to achieve cardioprotection. …

… to modulate endogenous antioxidant systems. Activation of Nrf2 reduces cell damage while
… Metformin can activate AMPK by phosphorylation of the key regulatory site (Thr-172) on the …

… of the injected cells as cardioprotective and cardio-reparative … and reach target sites far from
their primary release site. These … Harnessing the cellular and molecular basis of this cell-to-…

… Together, these enzymes form key nodes to produce and regulate endogenous H 2 S production.
… While few, if any, studies have proven a cardioprotective role for CBS, mutations in this …

… cell death 1)/PD-L1 (programmed death ligand 1) are designed to activate antitumor T
lymphocytes to harness … is decreased ERK activity and increased endogenous ERK inhibitor. In …

… Polhemus, DJ; Calvert, JW; Butler, J.; Lefer, DJ The cardioprotective actions of hydrogen
sulfide in acute myocardial infarction and heart failure. Scientifica 2014, 2014, 768607. […

… Cardiomyocytes also have relatively low endogenous antioxidant defenses; thus, … fundamental
regulators of cell signaling (53). Inhibition of specific kinases can be harnessed to combat …

… of cardioprotection by numerous pharmacological and non-pharmacological interventions,
such as ischaemic conditioning. An important component of the cardioprotective … cardiac cell …

… (eg at flavin or quinone sites of mitochondrial enzymes) [22]. … Figure 1 summarizes the major
sources of mitochondrial and … constitutive and inducible endogenous negative regulator of …

… have demonstrated the cardioprotective effects of elevating … Endogenous SCFAs are generated
primarily as products of … salutary effects that can be harnessed in the treatment of patients …