HLA imputation and its application to genetic and molecular fine-mapping of the MHC region in autoimmune diseases

T Naito, Y Okada - Seminars in immunopathology, 2022 - Springer
… for immune responses and inflammatory pathways [1, 2]. … SLE rather than its tagged
HLA-DRB1*03:01, which had been … , MHC fine-mapping studies have successfully identified the …

Association with HLA-DRβ1 position 37 distinguishes juvenile dermatomyositis from adult-onset myositis

CT Deakin, J Bowes, LG Rider, FW Miller… - Human molecular …, 2022 - academic.oup.com
… the most common idiopathic inflammatory myopathy of children. … AH8.1 and HLA-DRB1 *
03:01, HLA-C * 02:02 and identify a … While JDM and adult-onset dermatomyositis (DM) share

Transethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals not only shared but also ethnicity-specific disease associations

F Degenhardt, G Mayr, M Wendorff… - Human molecular …, 2021 - academic.oup.com
Inflammatory bowel disease (IBD) is a chronic inflammatory … Notably, we identified DRB1 *
01:03, which was identified as … In the analysis of peptide-binding preferences for HLA-DRB1

The lupus susceptibility allele DRB1*03:01 encodes a disease-driving epitope

B Miglioranza Scavuzzi, V van Drongelen… - Communications …, 2022 - nature.com
… The HLA-DRB1*03:01 allele is a … identified SLE-relevant terms that were shared between
65-79*LE-treated human and mouse macrophages, including terms pertaining to inflammatory

Accurate MHC motif deconvolution of immunopeptidomics data reveals a significant contribution of DRB3, 4 and 5 to the total DR immunopeptidome

S Kaabinejadian, C Barra, B Alvarez, H Yari… - Frontiers in …, 2022 - frontiersin.org
… disease, and therefore identifying peptides that might induce T … mixture of peptides presented
by HLA-DRB1 (primary DRB) … The cells were grown in high density cultures in roller bottles …

High-resolution African HLA resource uncovers HLA-DRB1 expression effects underlying vaccine response

AJ Mentzer, AT Dilthey, M Pollard, D Gurdasani… - Nature Medicine, 2024 - nature.com
… , two scientific issues are shared in development pipelines for … variation across the major
histocompatibility complex, known in … and HLA-DRB4 expression, we again could not identify an …

MHC associations of ankylosing spondylitis in East Asians are complex and involve non-HLA-B27 HLA contributions

G Wang, TH Kim, Z Li, A Cortes, K Kim, SY Bang… - Arthritis research & …, 2020 - Springer
… characteristically causing chronic inflammation of the spine … In addition to HLA-B*27, we
identify further HLA-B and other … for ankylosing spondylitis through high-density genotyping of …

Exploring the HLA complex in autoimmunity: From the risk haplotypes to the modulation of expression

S Sartoris, G Del Pozzo - Clinical Immunology, 2024 - Elsevier
… The genes mapping at the HLA region show high density, … , inflammatory cell infiltrates,
and myositis autoantibodies, with … with HLA-DRB1*03 and -DRB1*04, while other HLA-DRB1

Trans-ethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals shared but also ethnicity-specific disease associations

MR Center, F Degenhardt, G Mayr… - Human Molecular …, 2021 - research.rug.nl
… 27 new associations and highlights diseasespecific patterns at shared loci. Nat. Genet., …
High-density mapping of the MHC identifies a shared role for HLA-DRB101:03 in inflammatory

The relationship between extreme inter-individual variation in macrophage gene expression and genetic susceptibility to inflammatory bowel disease

CL O'Brien, KM Summers, NM Martin, D Carter-Cusack… - Human Genetics, 2024 - Springer
… /C, HLA-A/F and HLA-DRB1/DRB5) in macrophages was associated … Siblings presumably
share some components of both … All of the individuals in this cohort were identified as being of …