… neutralization breadth and potency of N49P6, a near-pan-… a new class of CD4-binding-site-specific
antibodies that we refer … Focused evolution of HIV-1 neutralizing antibodies revealed …

… of the virus, antibodies could evolve to better recognize the … that will elicit antibodies of
high breadth from which viral … immunization step, the identified mutations were also applied to …

… Another rhesus antibody bound the CD4 binding site by CD4 … used a reciprocal neutralization
titer cutoff of ID 50 ≤ 0.05 … mapping, we identified, in the evolving viral quasispecies of …

… , V3 loop glycans, the CD4 binding site (CD4bs), the gp120-… with scFabs of the near–pan-neutralizing
antibodies 10E8v4 [a … to deliver exceptional neutralization breadth and potency …

… after years of virus-antibody co-evolution in their hosts 2,3 . … Like more recently identified
bNAbs 16,17 , b12 binds to an … ) and contributes limited width to DEER distance distributions 42 …

… to be a HIV-1 bnAb by comparing neutralisation breadth, … trimeric Env such as the CD4
binding site, trimer apex, high-… (MPER) and the more recently identified epitope referred to as the ‘…

… of the CD4-binding site requires extensive antibody somatic … the neutralization breadth of
anti-FP vaccines and antibodies, … an antibody improvement campaign to identify this improved …

… identified a minimally mutated version of VRC01-class antibodies that retains neutralization
breadth … vaccine design given their near pan-neutralizing activity across HIV-1 viral clades (1…

… neutralizing Ab (bNAb) responses toward the conserved HIV-1 envelope (Env) CD4 binding
site (… neutralization against SIV pseudovirus (ID 50 above 50) were excluded from virus …

… with neutralizing breadth can also be observed in HIV-1 … epitopes (most notably, the CD4
binding site) and associated clinical … the identification of the near-pan neutralizing CD4bs bNAb …