Integration analysis of methylation quantitative trait loci and GWAS identify three schizophrenia risk variants

H Yu, W Cheng, X Zhang, X Wang, W Yue - …, 2020 - nature.com
… a study to identify genetic loci influencing cognitive function, including general cognitive function
(N … Taking all the evidence together, we hypothesize a potential mechanism in which the …

Joint-tissue integrative analysis identified hundreds of schizophrenia risk genes

Y Wu, XL Yu, X Xiao, M Li, Y Li - Molecular Neurobiology, 2022 - Springer
… the relationship between gene expression and trait, but we … in the pathogenesis of
schizophrenia by influencing fetal … GWAS of schizophrenia has identified a total of 270 risk loci, …

Identifying common genome-wide risk genes for major psychiatric traits

S Liu, S Rao, Y Xu, J Li, H Huang, X Zhang, H Fu… - Human genetics, 2020 - Springer
… Characterizing the cross-disorder/trait genetic influences … is located within the LINC00461
gene locus (Supplemental Fig. 5… However, our findings, together with previous results, indicate …

Polygenic risk scores shed light on the relationship between schizophrenia and cognitive functioning: review and meta-analysis

J Mallet, Y Le Strat, C Dubertret, P Gorwood - Journal of clinical medicine, 2020 - mdpi.com
… of genetic loci implicated in the modulation of cognitive abilities in … All together, these latter
findings suggest that in patients with … If the same genes influence cognition in schizophrenia

Investigating the effects of genetic risk of schizophrenia on behavioural traits

A Socrates, J Maxwell, KP Glanville, M Di Forti… - … schizophrenia, 2021 - nature.com
… Next, to identify potential disorder or medication effects, we … factors influencing tea consumption
and schizophrenia risk, … AS and JM as joint first authors performed all the analyses and …

Characterising the shared genetic determinants of bipolar disorder, schizophrenia and risk-taking

G Hindley, S Bahrami, NE Steen, KS O'Connell… - Translational …, 2021 - nature.com
… We identified 192 loci jointly associated with SCZ and risk … , suggesting most variants
influence multiple traits with few … We next used conjFDR to identify specific genetic loci jointly

[HTML][HTML] Interactome overlap between schizophrenia and cognition

E Koch, B Rosenthal, A Lundquist, CH Chen… - Schizophrenia …, 2020 - Elsevier
… To identify genes related to schizophrenia and cognitive … controls, which identified 108
independent loci associated with … (cognition-associated genes), together with all the within-trait/…

Effect of schizophrenia risk gene polymorphisms on cognitive and neural plasticity

W Zhao, Q Zhang, Y Su, X Chen, X Li, B Du… - Schizophrenia …, 2022 - Elsevier
… This study found that 58 SNPs in 56 gene loci outside the … Taken together, KCNV1 seems
to play an important role in … could not examine the influence of genetic factors on the transfer …

The relationship between polygenic risk scores and cognition in schizophrenia

…, Schizophrenia Working Group of the … - Schizophrenia …, 2020 - academic.oup.com
… disorders and cognitive traits in multiple schizophrenia case … Together, these considerations
support the hypothesis that … schizophrenia risk alleles or genes influence cognition or EA, …

Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence

OB Smeland, S Bahrami, O Frei, A Shadrin… - Molecular …, 2020 - nature.com
influencing these phenotypes, we applied a conditional false … cognitive abilities, where most
(18 out of 21) SCZ risk alleles … enrichment and identified 75 genomic loci jointly associated …