Immunogenicity and immunodominance in antibody responses

M Vogel, MF Bachmann - Vaccination Strategies Against Highly Variable …, 2020 - Springer
Influenza virus may be a point in case, where an antiviral titer of 1:64 (measured by
hemagglutinationInfluenza viruses are RNA viruses and are divided into three different types, …

Imprinting, immunodominance, and other impediments to generating broad influenza immunity

M Knight, S Changrob, L Li… - Immunological reviews, 2020 - Wiley Online Library
… to Ag in vivo: implications for vaccine development and … , hemagglutinin, and neuraminidase
can easily mutate their … and epitopic variants, influenza virus is capable of narrowing the …

[HTML][HTML] The immunodominance of antigenic site Sb on the H1 influenza virus hemagglutinin increases with high immunoglobulin titers of the cohorts and with young …

JL Martínez, N Lemus, TY Lai, M Mishra… - Vaccine, 2024 - Elsevier
… Given that age, vaccination history, and HI titers were similar between females and males,
we were able to analyze the direct effect of sex on displaying an immunodominance profile …

Deciphering and predicting CD4+ T cell immunodominance of influenza virus hemagglutinin

A Cassotta, P Paparoditis, R Geiger, RR Mettu… - Journal of Experimental …, 2020 - rupress.org
… regions and reveals modulation for antigen processing by antibodies … + T cell
immunodominance could be primarily related to the yield of peptides generated by antigen

Subdominance in antibody responses: implications for vaccine development

G Lindahl - Microbiology and Molecular Biology Reviews, 2020 - Am Soc Microbiol
… FIG 5 Hemagglutinin (HA) of influenza virus: subdominant … , because both antigenic variation
and subdominance are … the HA of influenza virus demonstrated that immunodominant sites …

Influenza hemagglutinin structures and antibody recognition

NC Wu, IA Wilson - Cold Spring Harbor …, 2020 - perspectivesinmedicine.cshlp.org
… the ability to agglutinate red blood cells, which enables rapid quantification of influenza virus
(hemagglutination assay) as well as the virus-neutralizing capacity of antibodies and sera (…

Defining and manipulating B cell immunodominance hierarchies to elicit broadly neutralizing antibody responses against influenza virus

A Amitai, M Sangesland, RM Barnes, D Rohrer… - Cell Systems, 2020 - cell.com
… from key sites of virus vulnerability. We … of immunodominance that evolve upon immunization
with natural and engineered displays of hemagglutinin (HA), the influenza vaccine antigen. …

The emergence of new antigen branches of H9N2 avian influenza virus in China due to antigenic drift on hemagglutinin through antibody escape at immunodominant …

N Zhang, K Quan, Z Chen, Q Hu, M Nie… - Emerging microbes & …, 2023 - Taylor & Francis
… control measure against H9N2 avian influenza viruses (AIVs) that … antigenic drift of
hemagglutinin (HA) under antibody pressure, leading to the emergence of immune escape variants. …

Antigenic variability

AI Mosa - Frontiers in Immunology, 2020 - frontiersin.org
… of immunodominance and antigenic variability render … immunodominance of the mutationally
tolerant regions, in this case the globular head of the surface glycoprotein hemagglutinin

[HTML][HTML] Preexisting subtype immunodominance shapes memory B cell recall response to influenza vaccination

RB Abreu, GA Kirchenbaum, EF Clutter, GA Sautto… - JCI insight, 2020 - ncbi.nlm.nih.gov
… vaccines offer variable effectiveness due to seasonal antigenic variants (9). There are 5 …
HA and neuraminidase (NA) are the 2 main surface glycoproteins expressed in influenza viral