Safety and immunogenicity of an HIV-1 prefusion-stabilized envelope trimer (Trimer 4571) vaccine in healthy adults: A first-in-human open-label, randomized, dose …
KV Houser, MR Gaudinski, M Happe, S Narpala… - …, 2022 - thelancet.com
… limited in size, our results inform and support further evaluation of prefusion-stabilized HIV-1
envelope trimers … focused on the exposed glycan-free base of the soluble Env trimer. This …
envelope trimers … focused on the exposed glycan-free base of the soluble Env trimer. This …
Structure‐guided envelope trimer design in HIV‐1 vaccine development: a narrative review
R Derking, RW Sanders - Journal of the International AIDS …, 2021 - Wiley Online Library
… with reduced exposure of non-neutralizing epitopes. Cell. … -like HIV-1 envelope trimers to
silence nonneutralizing epitopes and … and immunogenicity of a stabilized HIV-1 envelope trimer …
silence nonneutralizing epitopes and … and immunogenicity of a stabilized HIV-1 envelope trimer …
Antigenicity and immunogenicity of hiv-1 envelope trimers complexed to a small-molecule viral entry inhibitor
SM Alam, K Cronin, R Parks, K Anasti, H Ding… - Journal of …, 2020 - Am Soc Microbiol
… (CD4i) exposure of epitopes of non-neutralizing antibodies … we hypothesized that such
stabilized trimer immunogens will … with reduced exposure of non-neutralizing epitopes. Cell 163…
stabilized trimer immunogens will … with reduced exposure of non-neutralizing epitopes. Cell 163…
Stepwise conformational stabilization of a HIV-1 clade C consensus envelope trimer immunogen impacts the profile of vaccine-induced antibody responses
A Hauser, G Carnell, K Held, G Sulbaran… - Vaccines, 2021 - mdpi.com
… The HIV-1 Envelope surface glycoprotein (Env) is a trimer of … of epitopes that induce
non-neutralizing antibodies [10]. This is … immunogenicity with increasing degree of stabilization …
non-neutralizing antibodies [10]. This is … immunogenicity with increasing degree of stabilization …
High thermostability improves neutralizing antibody responses induced by native-like HIV-1 envelope trimers
RA Russell, EE Schermer, CA Cottrell, JD Allen… - NPJ …, 2022 - search.proquest.com
… the immunogenicity of a palette of BG505-based SOSIP trimers … in the exposure of
immunodominant non-neutralizing antibody … and immunogenicity of a stabilized HIV-1 envelope …
immunodominant non-neutralizing antibody … and immunogenicity of a stabilized HIV-1 envelope …
Potent induction of envelope-specific antibody responses by virus-like particle immunogens based on HIV-1 envelopes from patients with early broadly neutralizing …
C Beltran-Pavez, I Bontjer, N Gonzalez… - Journal of …, 2022 - Am Soc Microbiol
… Here, we describe 5 HIV-1 envelope sequences from individuals who have developed …
Immunogenicity of stabilized HIV-1 envelope trimers with reduced exposure of non-neutralizing …
Immunogenicity of stabilized HIV-1 envelope trimers with reduced exposure of non-neutralizing …
High thermostability improves neutralizing antibody responses induced by native-like HIV-1 envelope trimers
I del Moral-Sánchez, RA Russell, EE Schermer… - npj Vaccines, 2022 - nature.com
… immunogenicity of a palette of BG505-based SOSIP trimers … in the exposure of
immunodominant non-neutralizing antibody … We further stabilized the prefusion sequestered …
immunodominant non-neutralizing antibody … We further stabilized the prefusion sequestered …
Stabilized diverse HIV-1 envelope trimers for vaccine design
Q Wang, B Ma, Q Liang, A Zhu, H Wang… - Emerging microbes & …, 2020 - Taylor & Francis
… We previously characterized a large panel of full-length HIV-1 envelope clones from …
Immunogenicity of stabilized HIV-1 envelope trimers with reduced exposure of non-neutralizing …
Immunogenicity of stabilized HIV-1 envelope trimers with reduced exposure of non-neutralizing …
Development of a 3mut-apex-stabilized envelope trimer that expands HIV-1 neutralization breadth when used to boost fusion peptide-directed vaccine-elicited …
… Immunogenicity of stabilized HIV-1 envelope trimers with reduced exposure of non-neutralizing …
Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M …
Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M …
Augmenting the immune response against a stabilized HIV-1 clade C envelope trimer by silica nanoparticle delivery
D Peterhoff, S Thalhauser, JM Sobczak, MO Mohsen… - Vaccines, 2021 - mdpi.com
… The delivery of HIV-1 envelope (Env) trimer-based … Finally, we show that SiNPs enhance
immunogenicity of Env … gp41 directed non-neutralizing antibody 5F3 were generally low, with …
immunogenicity of Env … gp41 directed non-neutralizing antibody 5F3 were generally low, with …