[图书][B] A computational study of cisplatin and its derivatives towards the analysis, improvement and design of anticancer agents

PS Pole - 2021 - search.proquest.com
… to further understand properties such as the chemical reactivity, kinetic stability, and reactivity
descriptors that can further elaborate why some compounds are active against cancer cells…

Mathematical model predicts response to chemotherapy in advanced non-resectable non-small cell lung cancer patients treated with platinum-based doublet

E Kozłowska, R Suwiński, M Giglok… - PLoS Computational …, 2020 - journals.plos.org
… with platinum doublet[11]. Here, we focus on the platinum doublet palliative treatment of
non-small cell lung carcinoma. Mathematical models could contribute to personalized cancer

Genotyping, in silico screening and molecular dynamics simulation of SNPs of MGMT and ERCC1 gene in lung cancer patients treated with platinum-based doublet …

S Singh, A Gupta, N Singh, PS Sengupta… - Journal of …, 2023 - Taylor & Francis
Full article: Genotyping, in silico screening and molecular dynamics simulation of SNPs of
MGMT and ERCC1 gene in lung cancer patients treated with platinum-based doublet

Efficacy of CDK4/6 inhibitors in preclinical models of malignant pleural mesothelioma

E Aliagas, A Alay, M Martínez-Iniesta… - … Journal of Cancer, 2021 - nature.com
… After 26 days of treatment, we quantified the macrophages … of mice compared with
cisplatin-based chemotherapy or vehicle; … after standard chemotherapy doublet treatment. Finally, …

From tumour perfusion to drug delivery and clinical translation of in silico cancer models

M Hadjicharalambous, PA Wijeratne, V Vavourakis - Methods, 2021 - Elsevier
… of the efficacy of cisplatin-based doublet regimens; thus, their framework can be used for
quantitative estimation of the in vivo cell-killing ability of various avenues of chemotherapy. …

[HTML][HTML] … in personalized in silico oncology: coupling cell kinetics with metabolism, signaling networks, and biomechanics as plug-in component models of a cancer …

E Kolokotroni, D Abler, A Ghosh, E Tzamali… - Journal of personalized …, 2024 - mdpi.com
… The core algorithms of the Lung and WT Oncosimulators have been previously developed
by the In Silico Oncology and In Silico Medicine Group, and the implementation details can be …

[HTML][HTML] MicroRNA expression profiling and biomarker validation in treatment-naïve and drug resistant non-small cell lung cancer

L MacDonagh, MF Gallagher, B Ffrench… - … lung cancer research, 2021 - ncbi.nlm.nih.gov
… checkpoints, cisplatin-doublet chemotherapy remains the … micro-dissection/determination
of cancer cell percentages from … predicting response to cisplatin-based chemotherapy and the …

miRNome profiling of lung cancer metastases revealed a key role for miRNA-PD-L1 axis in the modulation of chemotherapy response

R Cuttano, T Colangelo, J Guarize, E Dama… - … Hematology & Oncology, 2022 - Springer
… (NACT; platinum-based doublet (P-doublet)) before surgery to target nodal … cisplatin-based
chemotherapy, to trigger the immune response against primary and metastatic lung cancer

Smart Sensors and Microtechnologies in the Precision Medicine Approach against Lung Cancer

GM Stella, S Lettieri, D Piloni, I Ferrarotti, F Perrotta… - Pharmaceuticals, 2023 - mdpi.com
… four cycles of cisplatin-based doublets (mainly vinorelbine, less … and quantification of activating
mutations in lung cancer is … From the start of in silico DNA amplification with polymerase …

Heteroleptic Pd (II) and Pt (II) Complexes with Redox-Active Ligands: Synthesis, Structure, and Multimodal Anticancer Mechanism

NF Romashev, PA Abramov, IV Bakaev… - Inorganic …, 2022 - ACS Publications
… The anticancer activity of Pd complexes in breast cancer cell … -Bian) complexes demonstrated
anticancer activity in a low … In order to quantify the fluorescent quenching, we plotted I 0 /I …