Porphyromonas gingivalis gingipains induce cyclooxygenase-2 expression and prostaglandin E2 production via ERK1/2-activated AP-1 (c-Jun/c-Fos) and IKK/NF-κB …

M Nakayama, M Naito, K Omori, S Ono… - The Journal of …, 2022 - journals.aai.org
… with gingipain-induced COX-2 expression. To clarify the transcription factors regulated by
ERK1/2 in gingipain-induced COX-2 expression, we examined the level of expression and …

AP-1 family transcription factors: a diverse family of proteins that regulate varied cellular activities in classical hodgkin lymphoma and ALK+ ALCL

Z Wu, M Nicoll, RJ Ingham - Experimental hematology & oncology, 2021 - Springer
… of some AP-1 proteins in cHL and ALK+ ALCL. Forced expression of dominant negative A-…
sensitive to staurosporine and doxorubicin-induced apoptosis [110]. This suggests that GzB …

Up-regulation of PTEN via LPS/AP-1/NF-κB pathway inhibits trophoblast invasion contributing to preeclampsia

P Xue, W Fan, Z Diao, Y Li, C Kong, X Dai, Y Peng… - Molecular …, 2020 - Elsevier
… of AP-1) and NF-κB activity after … induced PTEN expression is dependent on AP-1 and NF-κB
in trophoblasts, suggesting that AP-1 and NF-κB are positive regulators of PTEN expression

The role of AP-1 transcription factors in plasma cell biology and multiple myeloma pathophysiology

F Fan, K Podar - Cancers, 2021 - mdpi.com
… Specifically, we showed that BM-induced expression of JunB was significantly … -expressed
negative regulator of bone formation. Consequently, downregulation of Fra-1, Fra-2 and c-Jun

The potential of activator protein 1 (AP-1) in cancer targeted therapy

D Song, Y Lian, L Zhang - Frontiers in Immunology, 2023 - frontiersin.org
… with c-Jun increases c-Fos nuclear retention inhibits nuclear exit, … AP-1 and NF-κB dual
inhibitor SP100030 is one of the first reported small molecules to inhibit gene expression induced

[HTML][HTML] Zanthoxylum bungeanum seed oil inhibits RANKL-induced osteoclastogenesis by suppressing ERK/c-JUN/NFATc1 pathway and regulating cell cycle arrest …

F He, S Luo, S Liu, S Wan, J Li, J Chen, H Zuo… - Journal of …, 2022 - Elsevier
… the phosphorylation level of c-JUN. Thus, the inhibitory … genes were potentially via targeting
c-JUN/AP-1, instead of c-FOS, to suppress phosphorylation and subsequently downregulate

Induction of the proinflammatory chemokine interleukin-8 is regulated by integrated stress response and AP-1 family proteins activated during coronavirus infection

QC Zhu, S Li, LX Yuan, RA Chen, DX Liu… - International Journal of …, 2021 - mdpi.com
… , a rationally designed small molecule that inhibits the DNA binding activity of cFOS/cJUN,
would be of help in exploring … The dominant negative (DN) trans-activation mutant TAM-67 of …

Tanshinone IIA pretreatment promotes cell survival in human lung epithelial cells under hypoxia via AP-1-Nrf2 transcription factor

S Yadav, M Singh, SN Singh, B Kumar - Cell Stress and Chaperones, 2020 - Springer
… hypoxia-induced oxidative stress by modulating the expression of AP-… of AP-1 heterodimer
and their regulated genes. Our data revealed the role of pc-jun/c-fos, pc-jun/fosB, junD/c-fos, …

[PDF][PDF] Differential effects of Platelet-derived growth factor on c-Jun-N-Terminal Kinase and AP-1/NF-κB activities in human glioblastoma T98G cells

E Parra, V Rojas, J Ferreira, P Hecht - researchgate.net
… The observation that expression of siRNA-JNK-1 strongly inhibits PMA and PDGF effect in …
activity of JNK-1 (probably by blocking the phosphorylation of c Jun) and the induction of AP-1

AP-1 signaling pathway promotes pro-IL-1β transcription to facilitate NLRP3 inflammasome activation upon influenza A virus infection

P Wan, S Zhang, Z Ruan, X Liu, G Yang, Y Jia, Y Li… - Virulence, 2022 - Taylor & Francis
c-Jun decreases pro-IL-1β mRNA and inhibits NLRP3 inflammasome activation upon IAV
infection. Overall, the findings uncover that AP-1 … mature Caspase-1 protein induced by H3N2 …