Cellular and molecular pathways of COVID-19 and potential points of therapeutic intervention

JP Hussman - Frontiers in pharmacology, 2020 - frontiersin.org
… These mechanisms are concordant with observed clinical markers in COVID-19, including
high expression of inflammatorypathway suggests multiple points of investigation for potential …

[HTML][HTML] Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets

M Farahani, Z Niknam, LM Amirabad… - Biomedicine & …, 2022 - Elsevier
… molecular mechanisms involved in COVID-19, which are initiated with ACE2 deficiency,
ADAM17 activation, and followed by the induction of pro-inflammatory pathways. In COVID-19

The interplay between inflammatory pathways and COVID-19: A critical review on pathogenesis and therapeutic options

S Choudhary, K Sharma, O Silakari - Microbial pathogenesis, 2021 - Elsevier
… In this article, we have provided the detailed mechanism of occurrence of SARS-CoV-2 …
on different inflammatory pathways that are mainly involved in the pathogenesis of COVID-19. …

The signal pathways and treatment of cytokine storm in COVID-19

L Yang, X Xie, Z Tu, J Fu, D Xu, Y Zhou - … and targeted therapy, 2021 - nature.com
… features of COVID-19, especially the CS; its mechanism of … COVID-19 cases, which represents
a potential interventioninflammatory pathways such as NF-κB and MAPK pathways to …

Therapeutic targets and interventional strategies in COVID-19: mechanisms and clinical studies

YW Zhou, Y Xie, LS Tang, D Pu, YJ Zhu… - … and targeted therapy, 2021 - nature.com
… of COVID-19, the therapeutic targets and interventions of … -2 and the tremendous
inflammatory/immune response to the … be potential inhibitors of type I IFN pathway. Moreover, a …

Inflammatory cytokine: IL-17A signaling pathway in patients present with COVID-19 and current treatment strategy

T Shibabaw - Journal of inflammation research, 2020 - Taylor & Francis
… and the synergic inflammatory cytokine IL-6 to manage COVID-19 patients, particularly those
… storm mechanisms in this disease could help to reveal possible therapeutic interventions. …

Role of inflammatory cytokines in COVID-19 patients: A review on molecular mechanisms, immune functions, immunopathology and immunomodulatory drugs to …

AA Rabaan, SH Al-Ahmed, J Muhammad, A Khan… - Vaccines, 2021 - mdpi.com
… in COVID-19 therapeutic interventions [150,151]. Inhibition of the JAK pathway represses the
… the JAK/STAT pathway is also considered as an effective therapeutic method to control the …

Pulmonary fibrosis from molecular mechanisms to therapeutic interventions: lessons from post-COVID-19 patients

C Giacomelli, R Piccarducci, L Marchetti… - Biochemical …, 2021 - Elsevier
… in the control of inflammation. The same authors also reveal an intriguing mechanism at the
… , and “non-canonical pathways” if other intracellular pathways are activated (eg the planer …

COVID-19 revisiting inflammatory pathways of arthritis

G Schett, B Manger, D Simon, R Caporali - Nature Reviews …, 2020 - nature.com
… , the safety of immune interventions during the pandemic. … the mechanisms of alveolar
inflammation in COVID-19 share … of cytokines involved in driving the inflammatory process. On the …

COVID-19 infection: an overview on cytokine storm and related interventions

S Montazersaheb, SM Hosseiniyan Khatibi, MS Hejazi… - Virology journal, 2022 - Springer
… the underlying mechanisms can aid in developing therapeutic … the leading cause of
inflammatory response in COVID-19 [19]. The … pathways of inflammatory cytokines aiming to …