CD36‐fibrin interaction propagates FXI‐dependent thrombin generation of human platelets

M Döhrmann, S Makhoul, K Gross, M Krause… - The FASEB …, 2020 - Wiley Online Library
… TSP-1 was purified from thrombinstimulated human platelets.FITC-… inhibition by PP1 (20áÁM)
in washed human platelets plus GPRP (2.5ámM) in the absence or presence of fibrinogen (…

[HTML][HTML] Effect of heparanase inhibitor on tissue factor overexpression in platelets and endothelial cells induced by anti‐β2‐GPI antibodies

A Capozzi, G Riitano, S Recalchi, V Manganelli… - Journal of Thrombosis …, 2021 - Elsevier
… GPI complex binds to the platelet thrombus and amplifies platelet activation… , proteins,
monoclonal antibodies, and nucleic acids. … Unstimulated human platelets or stimulated with …

Platelet binding to polymerizing fibrin is avidity driven and requires activated αIIbβ3 but not fibrin cross-linking

L Buitrago, S Lefkowitz, O Bentur, J Padovan… - Blood …, 2021 - ashpublications.org
… sought to inhibit the rapid interactions between platelets and … Human platelets treated with
the peptide RGDW show a fibrin… when stimulated with Thr and RGDW, the patient’s platelets

Targeting platelet inhibition receptors for novel therapies: PECAM-1 and G6b-B

EM Soriano Jerez, JM Gibbins, CE Hughes - Platelets, 2021 - Taylor & Francis
… This allows the binding of fibrinogen, platelet aggregation … other studies in human platelets
suggest expression levels … -B stimulation could lead to less reactive platelets, reducing …

[HTML][HTML] Functional plasminogen activator inhibitor 1 is retained on the activated platelet membrane following platelet activation

GB Morrow, CS Whyte, NJ Mutch - haematologica, 2020 - ncbi.nlm.nih.gov
Platelets anchor to fibrinogen via the integrin α IIb β 3 ; this … -1 on the membrane of platelets
stimulated on a collagenand … PAI-1 and TAFIa, 62 monoclonal antibodies to PAI-1 and TAFIa, …

[HTML][HTML] Activated platelets kill Staphylococcus aureus, but not Streptococcus pneumoniae—The role of FcγRIIa and platelet factor 4/heparinantibodies

M Wolff, S Handtke, R Palankar, J Wesche… - Journal of Thrombosis …, 2020 - Elsevier
platelets were unresponsive to TRAP‐6 stimulation and … The use of human sera with HIT
antibodies and human platelets … , or PAC‐1 binding was inhibited either by fibrinogen, released …

… Protein Disulfide Isomerase (PDI) Binding to Platelets and Production of a Murine Monoclonal Antibody (mAb) to Integrin αIIbβ3 That Inhibits PDI Binding and Platelet …

L Wang, J Wang, J Li, T Walz, BS Coller - Blood, 2023 - Elsevier
Human platelets and Alexa-488-PDI were stimulated with a … control; p < 0.05)], fibrinogen
binding (6,493 ą 815 vs 15,058 ą … to human platelets (21D10) that can inhibit T6-induced PDI …

An αIIbβ3 monoclonal antibody traps a semiextended conformation and allosterically inhibits large ligand binding

L Wang, J Wang, J Li, T Walz, BS Coller - Blood Advances, 2024 - ashpublications.org
… Using human platelets as the immunogen, we identified a … it inhibited fibrinogen binding to
eptifibatide-primed platelets by … on PDI binding to human and murine platelets stimulated with …

Myricetin as a promising inhibitor of platelet fibrinogen receptor in humans

Y Chang, CW Hsia, WC Huang, T Jayakumar, CH Hsia… - Heliyon, 2023 - cell.com
… of myricetin to inhibit platelet aggregation stimulated by collagen, … Anti-phospho PLCγ2
monoclonal antibody (mAb) was … release stimulated by agonists in washed human platelets. (A) …

Generation of human antibodies targeting human platelet antigen (HPA)‐1a

JJ Oosterhoff, F Linty, R Visser, T de Vos… - …, 2024 - Wiley Online Library
… for 10 days to stimulate antibody production. Subsequently, … inhibition of megakaryopoiesis
20 and decreased fibrinogen … of recombinant platelet-specific monoclonal antibodies and …