… appropriate statistical modeling of large-scale biobank data. … a causal relationship between
ANM and breast cancer, heart … pathways associated with the hypothalamic-pituitary-gonadal (…

… based GWAS, pathway analysis and linkage … genetic instrumental variables for AMH. For
the outcomes, we included summary statistics from recent large-scale GWASs for breast cancer …

… Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast
cancer susceptibility and BRCA1-mediated DNA repair. Nat Genet 2015;47:1294–1303. …

… a 10 % decrease in the risk of breast cancer [41]. However, … -related changes in the
hypothalamic-pituitary-ovarian axis … of successful use of such large-scale studies is that the …

… Here we identify 290 genetic determinants of ovarian ageing, assessed using normal …
inference analyses using the identified genetic variants indicate that extending reproductive life in …

… Summary statistics for 122,977 cases of breast cancer and … microenvironment and is linked
to cancer risk and metastasis [… effects but also to interrupt its pathway in other related nodes. …

… underlie the genetic links between ANM and breast cancer. … Large-scale GWAS improves
discovery of risk variants and … Genomic analyses identify hundreds of variants associated …

… in central nervous system tissues including the hypothalamus and pituitary gland. Cross-trait …
, although the relationship is complex and dependent on stage of reproductive aging. …

… at the hypothalamic–pituitary and ovarian levels, thus regulating ovarian ageing (Stolk et al.,
… STRING signalling pathway analysis showed that breast cancer gene BRCA1 is associated …

… of the etiology of menopause and female aging, as well as shed … pathway seems to be
essential for the development of basal-like breast cancers and high-grade serous ovarian cancers …