… We applied a large-scale molecular epidemiology approach … hypothesis that links shift work
with elevated breast-cancer risks our … located in the SCN of the hypothalamus [42], and our …

… variants of these genes deserve further intensive investigation via genetic analysis. …
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer …

… on the integrity of the hypothalamus, pituitary and liver. The … for PCOS and the lack of
large-scale prospective data. Given the … is a link between IGF-1 signalling and breast cancer risk. …

… confirmed by recent large-scale genome-wide association … cancer 37 , estrogen receptor
negative (ER-) breast cancer and … Our pathway and enrichment analyses showed involvement …

… Oxidative stress has also been linked to male reproductive … Investigating if gene mutations
in the DDR pathway accelerate … Whole-genome analysis-based strategies may help to …

… on AAM by performing a large-scale TWAS for AAM based on … Day et al. performed an
expanded genomic analysis of AAM … considered a potential drug for treating breast cancer (63, 64)…

… : Estrogen signaling mediated DNA repair in breast cancer. … (45) Large-scale whole-genome
sequencing data confirm TF … via suppression of the hypothalamic-pituitary-gonadal axis (…

… Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast
cancer susceptibility and BRCA1-mediated DNA repair. Nat Genet 47, 1294-1303 (2015). https://…

… As the hypothalamus assures the connection between the … In many breast cancers, ERα
activation by estrogens is … In particular, the estrogen signaling in the hypothalamus contributes to …

… such as ovarian and breast cancers. Gender-affirming … estradiol by means of fast signaling
transcriptional activation. All … the restraint on both the hypothalamus and pituitary, resulting in …