… We propose that comparative immunogenomics offers a solution to the problem of estimating past selection on immune genes. Specifically, long-read sequencing (LRseq) technology …
… 4: Transcriptomic analyses of HPB revealunique pathway … Therefore, we believe that extensions of healthspan and … has yet to be demonstrated using a longitudinal model. It is critical …
… Single-cell transcriptomicsreveals expansion of cytotoxic CD4 T cells in supercentenarians. … Single-cell transcriptomicsreveals expansion of cytotoxic CD4 T cells in supercentenarians. …
N Raghavachari, B Wilmot… - … of Gerontology: Series A, 2022 - academic.oup.com
… , and it is leveraging unique and very large human study … , healthy long-lived individuals, longitudinal and pedigree data … with human longevity and healthspan. These variants will also …
LA Mavromatis, DB Rosoff, AS Bell, J Jung… - Nature …, 2023 - nature.com
… Here, we use multi-omic methods to integrate genomic, transcriptomic, and metabolomic … healthspan, lifespan, and exceptional longevity (multivariate longevity). Using transcriptomic …
W Liu, P Zhu, M Li, Z Li, Y Yu, G Liu, J Du, X Wang… - bioRxiv, 2023 - biorxiv.org
… comparison of age-related transcriptomic changes in Myotis, human, mouse and wolf. Myotis exhibits unique molecular mechanisms for lifespan extension … obtained transcriptome data …
M Takasugi, Y Yoshida, Y Nonaka… - Nucleic Acids …, 2023 - academic.oup.com
… of long-lived species would help to reveal pro-longevity genetic programs. Transcriptomic analysis of exceptionally long-… that might potentially support their long lifespan. In a milestone …
W Liu, P Zhu, M Li, Z Li, Y Yu, G Liu, J Du… - The EMBO …, 2023 - embopress.org
… a comparativetranscriptomics … comparison of age-related transcriptomic changes in a long-lived Myotis bat species, human, mouse, and wolf revealed that Myotis bats exhibit unique …
… molecular mechanismsunderlying their extendedhealthspan are not well understood. Here, drawing on >8 years of mark-recapture field studies, we report the first longitudinal analysis …