[PDF][PDF] Comparative transcriptomics reveals circadian and pluripotency networks as two pillars of longevity regulation

JY Lu, M Simon, Y Zhao, J Ablaeva, N Corson, Y Choi… - Cell metabolism, 2022 - cell.com
… Here, by performing extensive comparative transcriptomics analysis, we revealed common
paths to … aimed to enhance DNA repair are a promising strategy to extend human healthspan. …

[HTML][HTML] Immunity and lifespan: answering long-standing questions with comparative genomics

EA O'Connor, CK Cornwallis - Trends in Genetics, 2022 - cell.com
… We propose that comparative immunogenomics offers a solution to the problem of estimating
past selection on immune genes. Specifically, long-read sequencing (LRseq) technology …

Multi-omic rejuvenation and lifespan extension on exposure to youthful circulation

B Zhang, DE Lee, A Trapp, A Tyshkovskiy, AT Lu… - Nature Aging, 2023 - nature.com
… 4: Transcriptomic analyses of HPB reveal unique pathway … Therefore, we believe that
extensions of healthspan and … has yet to be demonstrated using a longitudinal model. It is critical …

[HTML][HTML] Multi-modal profiling of peripheral blood cells across the human lifespan reveals distinct immune cell signatures of aging and longevity

TT Karagiannis, TW Dowrey, C Villacorta-Martin… - …, 2023 - thelancet.com
… Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians.
… Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians. …

… translational research for exceptional health and life span: a systematic narrative of studies to identify translatable therapeutic target (s) for exceptional health span in …

N Raghavachari, B Wilmot… - … of Gerontology: Series A, 2022 - academic.oup.com
… , and it is leveraging unique and very large human study … , healthy long-lived individuals,
longitudinal and pedigree data … with human longevity and health span. These variants will also …

[HTML][HTML] Multi-omic underpinnings of epigenetic aging and human longevity

LA Mavromatis, DB Rosoff, AS Bell, J Jung… - Nature …, 2023 - nature.com
… Here, we use multi-omic methods to integrate genomic, transcriptomic, and metabolomic …
healthspan, lifespan, and exceptional longevity (multivariate longevity). Using transcriptomic

Evolutionary transcriptomics reveals longevity mostly driven by polygenic and indirect selection in mammals

W Liu, P Zhu, M Li, Z Li, Y Yu, G Liu, J Du, X Wang… - bioRxiv, 2023 - biorxiv.org
comparison of age-related transcriptomic changes in Myotis, human, mouse and wolf. Myotis
exhibits unique molecular mechanisms for lifespan extension … obtained transcriptome data …

Gene expressions associated with longer lifespan and aging exhibit similarity in mammals

M Takasugi, Y Yoshida, Y Nonaka… - Nucleic Acids …, 2023 - academic.oup.com
… of long-lived species would help to reveal pro-longevity genetic programs. Transcriptomic
analysis of exceptionally long-… that might potentially support their long lifespan. In a milestone …

Large‐scale across species transcriptomic analysis identifies genetic selection signatures associated with longevity in mammals

W Liu, P Zhu, M Li, Z Li, Y Yu, G Liu, J Du… - The EMBO …, 2023 - embopress.org
… a comparative transcriptomicscomparison of age-related transcriptomic changes in a
long-lived Myotis bat species, human, mouse, and wolf revealed that Myotis bats exhibit unique

[HTML][HTML] Evolution of mammalian longevity: age-related increase in autophagy in bats compared to other mammals

J Kacprzyk, AG Locatelli, GM Hughes, Z Huang… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
… molecular mechanisms underlying their extended healthspan are not well understood. Here,
drawing on >8 years of mark-recapture field studies, we report the first longitudinal analysis …