… Going beyond UM-HET3, we expanded the search toward … Finally, more longitudinal data
collection accompanied by … of genetics of healthy aging or health span. There is therefore great …

… Especially in comparative studies dealing with the ageing field, it is needed to improve our
knowledge not only of transcriptome and genome sequences of these target species, but also …

… -related diseases altogether might be to target shared pathways underlying aging and cellular
maintenance. This is likely to result in prolonged healthspan and quality of life (Box 15.1). …

… for several chronic diseases that limit healthspan1. Mechanisms of aging are thus increasingly …
high consistency of the aging and sex proteomes across cohorts (Extended Data Fig. 2). …

… Several longitudinal aging studies uncovered an enrichment … ), a 10-year longitudinal aging
study comparing whole blood … with the previously described transcriptomic studies. However, …

… implications in the context of lifespan and healthspan extension. Adding years to life and even
… In this review, we will examine how interventions that have the potential to extend lifespan …

… By profiling the same mouse at multiple ages using a longitudinal analysis, we are able to …
elegans or yeast strains with a low rDNA burden, display an extended healthspan and hence …

… processes in males and females, resulting in distinct trajectories of disease. In this study,
we first reproduced and then expanded upon previously reported findings in the 3xTg-AD …

… The application of this predictive approach in longitudinal studies raises the possibility of …
reveal the underlying mechanisms of the aging process. Finally, age-based transcriptomic …

… Lifespan is not equal to healthspan. One can have a long lifespan with decades in bad
health without enjoying an equally long healthspan. Similarly, chronological age is not …