… -chain amino acid isoleucine promotes healthspan and extends lifespan when initiated in
young or … We monitored the mice longitudinally for 4 months with metabolic and behavioral …

… in improving healthspan and lifespan of model organisms. However, the mechanisms by which
… AMPK, mediating its effect on lifespan and healthspan extension in mice and C. elegans (…

… few long-lived species showing negligible signs of ageing. Approaches used to elucidate the
genetic mechanisms underlying … of convergent amino acid changes in long-lived lineages, …

The incidence of intestinal diseases increases with age, yet the mechanisms governing gut
aging and its link to diseases, such as colorectal cancer (CRC), remain elusive. In this study, …

We profiled the liver transcriptome, proteome, and metabolome in 347 individuals from 58
isogenic strains of the BXD mouse population across age (7 to 24 months) and diet (low or …

… down biological aging and extend healthspan. A reliable measure … A longitudinal approach
could also help identify more … , and 38 revealed that worse healthspan outcomes were linked …

… Proper manipulations of these signalling effectively extend both the healthspan and lifespan
of animals 1,2,3 . Therefore, it is vital to identify the molecular mechanisms underlying the …

… the participants over the longitudinal measurement time and … rate and healthspan of worms
has been described and shows the … on binarized transcriptomic data that extends beyond the …

… the aging process and increase the healthspan 10 , 11 . If … Given the association of Q i L G
S 5 with an extended lifespan… and controls recruited longitudinally in the LonGenity project at …

… elegans and clinical evidence have demonstrated that the control of lifespan and health
span are not identical 49,53 ; therefore, there is an increasing need to identify markers able to …