Fluids and their mechanics in tumour transit: shaping metastasis

G Follain, D Herrmann, S Harlepp, V Hyenne… - … Reviews Cancer, 2020 - nature.com
… diffuse down concentration gradients in interstitial fluid and guide dendritic cells towards
lymphatic vessels in mice 64 ; in tumours, similar mechanisms could favour the dissemination of …

Mechanosensitive piezo channels in cancer: focus on altered calcium signaling in cancer cells and in tumor progression

D De Felice, A Alaimo - Cancers, 2020 - mdpi.com
… multiple mechanisms to sense and tackle external mechanical … The mechanism of conversion
of physical stimuli into … This mechanism plays a critical role in various cellular processes…

Mechanical adaptability of tumor cells in metastasis

V Gensbittel, M Kräter, S Harlepp, I Busnelli, J Guck… - Developmental cell, 2021 - cell.com
… Here, we review the various mechanical requirements successful cancer cells might need to
fulfill … where arrested tumor cells exit blood circulation. Multiple mechanisms of extravasation …

The role of tumor microenvironment in cancer metastasis: Molecular mechanisms and therapeutic opportunities

CM Neophytou, M Panagi, T Stylianopoulos… - Cancers, 2021 - mdpi.com
… Moreover, the ECM applies mechanical forces on tumors that contribute to hypoxia and
cancer cell … Genetically modified platelets that express TRAIL can significantly eliminate the …

Solid stress, competition for space and cancer: The opposing roles of mechanical cell competition in tumour initiation and growth

R Levayer - Seminars in cancer biology, 2020 - Elsevier
… between mechanical cell competition and other mechanisms of … relevance of mechanical
cell competition in tumour initiation and … /alter spatial competition: modulating the mechanical

Mechanics of a multilayer epithelium instruct tumour architecture and function

VF Fiore, M Krajnc, FG Quiroz, J Levorse, HA Pasolli… - Nature, 2020 - nature.com
… predict will alter extensile tensions on the tumour basement … Our findings suggest that
mechanical forces—exerted from … Seeking alternative mechanisms that might affect tumour

Effect of nuclear stiffness on cell mechanics and migration of human breast cancer cells

T Fischer, A Hayn, CT Mierke - Frontiers in cell and developmental …, 2020 - frontiersin.org
effect of both nuclear and cytoskeletal mechanics on the overall cell mechanics, we firstly
altered nuclear mechanics … not yet identified mechanisms based on a direct TSA effect on the …

Physical traits of cancer

HT Nia, LL Munn, RK Jain - Science, 2020 - science.org
mechanisms. The resulting physical abnormalities affect both … used to detect cancer by
palpation), and (iv) altered physical … mechanical stresses with distinct origins and consequences (…

Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments

Z Yuan, Y Li, S Zhang, X Wang, H Dou, X Yu, Z Zhang… - Molecular cancer, 2023 - Springer
… These variations are under the control of cellular components in tumor tissue via the …
mechanical impact. Additionally, the ECM shaped by cancer regulates immune cells which results in …

[HTML][HTML] Mechanical tumor microenvironment and transduction: cytoskeleton mediates cancer cell invasion and metastasis

X Li, J Wang - International journal of biological sciences, 2020 - ncbi.nlm.nih.gov
… TRP channel directly or alter the membrane tension that … mechanical TME in cancer cell
migration and the actin cytoskeleton. We focused on essential mechanisms by which mechanical