Therapeutic effects of melatonin on ocular diseases: knowledge map and perspective

H Yu, Q Wang, W Wu, W Zeng, Y Feng - Frontiers in Pharmacology, 2021 - frontiersin.org
… , all the studies of melatonin in ocular diseases could be divided … in visual functions like
detection and color, and non-visual … #7 inflammation reflect the main research topics of melatonin

The therapeutic trip of melatonin eye drops: from the ocular surface to the retina

D Rusciano, C Russo - Pharmaceuticals, 2024 - mdpi.com
… biosynthesis is in the mitochondria (the major source of ROS … potential to protect our vision
from this debilitating disease. … , melatonin inhibited the gliosis activation and inflammatory

The Role and Therapeutic Potential of Melatonin in Degenerative Fundus Diseases: Diabetes Retinopathy and Age-Related Macular Degeneration

C Ma, H Li, S Lu, X Li - Drug Design, Development and Therapy, 2024 - Taylor & Francis
… of these diseases are crucial for preserving patients’ visual acuity. … and inflammatory
responses can influence melatoninsource for melatonin. Citation73 Researchers have identified …

A Clinical, Pharmacological, and Formulation Evaluation of Melatonin in the Treatment of Ocular Disorders—A Systematic Review

A Romeo, A Kazsoki, T Musumeci, R Zelkó - International Journal of …, 2024 - mdpi.com
… of free radicals and pro-inflammatory mediators. This study … therefore, MEL could be an
effective therapeutic resource [28]. … Given the increase in visual impairment in the world’s …

Melatonin receptor agonist ramelteon alleviates experimental acute ocular inflammation via HIF-1Α/VEGF/E-NOS signaling

G Usta Sofu, Y Erzurumlu, U Karaca… - European Journal …, 2023 - journals.sagepub.com
… While uveitis is a common reason for eye loss and vision disturbance, its etiology has yet to
… better understanding of the human disease (AAU), and may lead to the development of novel …

Mitochondrial dysfunction in age-related macular degeneration: melatonin as a potential treatment

S Mehrzadi, K Hemati, RJ Reiter… - … opinion on therapeutic …, 2020 - Taylor & Francis
… of the disease or to improve the visual function of suffering … Mitochondria are the main source
of H 2 O 2 in non-phagocytic … This anti–inflammatory effect of melatonin is suggested to be …

Melatonin, an endogenous hormone, modulates Th17 cells via the reactive-oxygen species/TXNIP/HIF-1α axis to alleviate autoimmune uveitis

J Huang, Z Li, Y Hu, Z Li, Y Xie, H Huang… - Journal of …, 2022 - Springer
… and anti-inflammatory properties of melatonin have attracted … process accounting for nearly
10% of cases of severe visual … found melatonin treatment attenuated the disease severity (…

Melatonin alleviates pyroptosis of retinal neurons following acute intraocular hypertension

Y Zhang, Y Huang, L Guo, Y Zhang… - … Disorders-Drug …, 2021 - ingentaconnect.com
… [30], reported that melatonin showed effects on visual … that melatonin could reduce the
retinal neurons of inflammation, … [33], demonstrated that melatonin treatment prevented the de…

[HTML][HTML] Melatonin: Unveiling the Functions and Implications in Ocular Health

J Zhang, H Zhou, Y Cai, S Yoshida, Y Li… - Pharmacological …, 2024 - Elsevier
… protects retinal ganglion cells by modulating aging and inflammatory pathways. Understanding
melatonin's … , necessitating BRB protection for disease treatment and vision restoration. …

The rationale for treating uveal melanoma with adjuvant melatonin: a review of the literature

A Hagström, R Kal Omar, PA Williams, G Stålhammar - BMC cancer, 2022 - Springer
… as an anti-inflammatory in both in vitro and in vivo models. … body, the primary source of
systemic melatonin is the pineal … exogenous melatonin may have benefits in a variety of diseases