Background Among children, sex-specific differences in disease prevalence, age of onset,
and susceptibility have been observed in health conditions including asthma, immune
response, metabolic health, some pediatric and adult cancers, and psychiatric disorders.
Epigenetic modifications such as DNA methylation may play a role in the sexual differences
observed in diseases and other physiological traits. Methods We performed a meta-analysis
of the association of sex and cord blood DNA methylation at over 450,000 CpG sites in 8438 …

Circulating vitamin B12 concentrations during pregnancy are associated with offspring
health. Foetal DNA methylation changes could underlie these associations. Within the
Pregnancy And Childhood Epigenetics Consortium, we meta-analysed epigenome-wide
associations of circulating vitamin B12 concentrations in mothers during pregnancy (n=
2,420) or cord blood (n= 1,029), with cord blood DNA methylation. Maternal and newborn
vitamin B12 concentrations were associated with DNA methylation at 109 and 7 CpGs …