Efficient homing of T cells via afferent lymphatics requires mechanical arrest and integrin-supported chemokine guidance

R Martens, M Permanyer, K Werth, K Yu… - Nature …, 2020 - nature.com
… Little is known regarding lymph node (LN)-homing of immune … of LN homing of afferent
lymph-derived lymphocytes (… floor endothelium until they encounter preformed entry ramps that …

New tools for immunologists: models of lymph node function from cells to tissues

T Ozulumba, AN Montalbine… - Frontiers in …, 2023 - frontiersin.org
… to facilitate encounters between APCs and rare antigen-specific lymphocytes, thus … , (ii)
distribution of major stromal cell subsets; (iii) homing of naïve T cells into the node via high …

[HTML][HTML] Integrative lymph node-mimicking models created with biomaterials and computational tools to study the immune system

Y Shou, SC Johnson, YJ Quek, X Li, A Tay - Materials Today Bio, 2022 - Elsevier
… of the lymphatic vessel network and the lymph node architecture with specific lymphocytes.
A) … Here they may encounter their cognate antigen presented by antigen-bearing migratory …

An Integrated Spatial Dynamics—Pharmacokinetic Model Explaining Poor Penetration of Anti-retroviral Drugs in Lymph Nodes

A Jagarapu, MJ Piovoso, R Zurakowski - Frontiers in bioengineering …, 2020 - frontiersin.org
… exploring the inflamed lymph node. Those lymphocytes that do not encounter cognate antigen
… Several different groups have introduced lymph node models, all focusing on lymphocyte

L-selectin-dependent and-independent homing of naïve lymphocytes through the lung draining lymph node support T cell response to pulmonary Mycobacterium …

L Daniel, C Counoupas, ND Bhattacharyya… - PLoS …, 2023 - journals.plos.org
… Defects in these processes observed in tumour models and … naïve lymphocytes to lung-draining
mediastinal lymph node … of the lymph node is to increase the probability of encounter

Modelling the effects of lymph node swelling on T-cell response

SC Johnson, J Frattolin, LT Edgar, M Jafarnejad… - bioRxiv, 2020 - biorxiv.org
… The lymphatic system is a network of organs and lymphatic … delivers crucial antigen information
to lymph nodes (LNs) for … blood to lymph nodes and its relation to lymphocyte traffic and …

Lymph Node-on-Chip Technology: Cutting-Edge Advances in Immune Microenvironment Simulation

Q Wang, Y Yang, Z Chen, B Li, Y Niu, X Li - Pharmaceutics, 2024 - mdpi.com
… the homing and localization of DC in the lymphatic system [52,… However, large molecules
encounter more resistance during … function is the unique spatial categorization of lymphocytes, …

Computational systems biology of cellular processes in the human lymph node

S Scharf, J Ackermann, P Wurzel, ML Hansmann… - Current opinion in …, 2024 - Elsevier
… We further emphasize that we focus on lymph node modelsmodeling techniques to explore
the human lymph node. To … as shape and motility, with a lymphocyte as a small figure. The …

Lymph node swelling combined with temporary effector T cell retention aids T cell response in a model of adaptive immunity

SC Johnson, J Frattolin, LT Edgar… - Journal of the …, 2021 - royalsocietypublishing.org
… Our modelling rules meant that LN swelling contributes to increased TC recruitment in a positive
… constrained in alternative models (electronic supplementary material, figure B in S5 file). …

Lymphatic endothelial cells of the lymph node

S Jalkanen, M Salmi - Nature Reviews Immunology, 2020 - nature.com
lymph node parenchyma and can themselves serve as antigen-presenting cells. The
leukocytes entering the lymph node via the sinus system and the lymphocytes … animal models. …