… , encoded by ARFGEF2). ARF1 GTP then can initiate vesicle formation through recruitment
of … Interestingly, in vitro and in vivo functional assays on ARF1 mutants have shown dominant …

… FLNA controls ARFGEF2-dependent ARF1 activation and regulates the migration of cortical
… ) Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and …

… Vesicle biogenesis, trafficking and signaling via the ER-Golgi network support … implicated
in the body curvature 394 defects observed in the embryos expressing the ARF3 mutants, we …

… Each of these coat proteins mediates a specific transport … To further investigate the effect of
the R99H mutation on … /or its regulators have been implicated in neuronal migration (46,47), …

… heterotopia present mutations in the ARFGEF2 (ADP-… exchange, regulating Golgi vesicular
budding and uncoating… cell biological features in neural progenitors implicated in the …

… mutants impair COP-I vesicle formation and cargo recycling in COS-1 cells Given the known
involvement of ARF GTPases in vesicles budding, endosomal transport, … how ARF3 mutants …

… in radial glia scaffolding, neuronal migration and proliferation of neural progenitors. PNH
also … Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and …

… Vesicular trafficking is a critical process in eukaryotic cells. It … used to generate the putative
mutant structures and to render … in a Turkish family with ARFGEF2 (periventricular heterotopia …

… The ability of stem cells to switch between quiescent and proliferative states is crucial for
tissue homeostasis. In the mammalian brain, most adult neural stem cells (NSCs) exist in a …

… heterotopia occurs within the neural progenitors along the … –cell adhesion and vesicle
trafficking. Pathogenic variants in … reported in FLNA-mutated and ARFGEF2-mutated patients,5 19 …