… No support for historical candidate gene or candidate gene-by-interaction hypotheses for
major depression across multiple large samples. Am J Psychiatry. 2019;176:376-87. …

… historical candidate genes for schizophrenia in light of results from a large genomic study, no
… ) effects to abandon the candidate gene approach and to take on the hypothesis-free GWA …

… and performed association studies at the polymorphism and gene level in multiple large
samples, found no support for candidate gene or candidate gene-by-interaction hypotheses for …

… hypothesis-driven candidate gene studies and hypothesis-… In general, studies focused
on single candidate genes or … could not perform any analyses with regard to family history, …

… in past month” and “felt distant from other people in past month,” had … our suggestive results
and test further our hypothesis. … new candidate genes and highlights polygenic transmission …

… Further, we discuss the findings supporting GxCA interactions, ranging from candidate gene
… from historic candidate gene and candidate gene-by-environment interaction hypotheses. …

… have not always accounted for ancestry. Using an empirical example of a proposed genetic
test for … , we show that genetic prediction using ML is vulnerable to ancestral confounding. …

… the role of common candidate genes in the development of … this hypothesis using a
genome-wide gene-gene interaction … been identified in the past, including genetic, psychological …

… Most genetic studies of suicidal behaviors are candidate gene analyses that, as … No
Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for …

… The hypothesis-driven (ie, candidate gene) approach for identifying specific variants associated
with a given outcome has not … Extrapolating from the history of GWASs in psychiatry, we …