Lifestyle, multi‐omics features, and preclinical dementia among Chinese: the Taizhou Imaging Study

…, X Chen, Taizhou Imaging Study Group - Alzheimer's & …, 2021 - Wiley Online Library
… for long-term longitudinal studies to advance Chinese cognitive aging and dementia
research. We initiated a community-based prospective cohort—the Taizhou Imaging Study (TIS)—to …

[PDF][PDF] Untangling determinants of enhanced health and lifespan through a multi-omics approach in mice

MA Aon, M Bernier, SJ Mitchell, C Di Germanio… - Cell metabolism, 2020 - cell.com
… Here, integrated analysis of physiological and multi-omics data … might be targeted for their
potential role in healthy aging. … Here, we performed liver and serum ‘‘multiomics’’ profiling in …

[HTML][HTML] Organ aging signatures in the plasma proteome track health and disease

HSH Oh, J Rutledge, D Nachun, R Pálovics, O Abiose… - Nature, 2023 - nature.com
… To translate these studies into transformative medicines, we must be able to accurately
measure aging across the body and understand the diversity of human aging not only across but …

[HTML][HTML] Common factors in neurodegeneration: a meta-study revealing shared patterns on a multi-omics scale

N Ruffini, S Klingenberg, S Schweiger, S Gerber - Cells, 2020 - mdpi.com
… However, no targeted therapies have emerged from these GWA studies for most NDDs [282].
As NDDs are causing profound transcriptomic changes in the aging brain, it is crucial to …

[HTML][HTML] The human body as a super network: Digital methods to analyze the propagation of aging

HJ Whitwell, MG Bacalini, O Blyuss, S Chen… - Frontiers in aging …, 2020 - frontiersin.org
… Modern ‘omics technologies are capable of acquiring large amounts of quantitative, or
semi-quantitative data (mass spectrometry, quantitative PCR, microarrays, etc.) relatively cheaply, …

[HTML][HTML] MetaboAge DB: a repository of known ageing-related changes in the human metabolome

T Bucaciuc Mracica, A Anghel, CF Ion, CV Moraru… - Biogerontology, 2020 - Springer
… for our society to study the biological mechanisms of human ageing in order to … ageing
processes in multicellular, eukaryotic systems, requires complex, multi-omics analyses as ageing

Molecular damage in aging

VN Gladyshev, SB Kritchevsky, SG Clarke, AM Cuervo… - Nature Aging, 2021 - nature.com
studies of the role of damage in human aging as well as aging of model organisms, which
could proceed with omics … biopsy tissues from existing human cohort studies. The association …

[HTML][HTML] Multi-omics approaches in immunological research

X Chu, B Zhang, VACM Koeken, MK Gupta… - Frontiers in …, 2021 - frontiersin.org
… other omics data layers. We demonstrate how recent studies applied a multi-omics approach
… different approaches and their importance in immunological studies. In the third section, we …

[HTML][HTML] Integrating environment and aging research: opportunities for synergy and acceleration

KMC Malecki, JK Andersen, AM Geller… - Frontiers in aging …, 2022 - frontiersin.org
Technological advances including next-generation sequencing and other-omics tools now
offer new opportunities, including exposomic research, to integrate aging biomarkers into …

Systems approaches to investigate the role of NF-κB signaling in aging

M Haga, M Okada - Biochemical Journal, 2022 - portlandpress.com
… In this review, we summarize how NF-κB regulates aging systems and how multi-omics and
… as learning and memory deficits, similar to those in human aging [84]. Pro-inflammatory, pro-…