… goal is to construct a mathematical model for studying the effect of tumor immunotherapy (…
We find the optimal control that is characterized in terms of the solution of the optimality system, …

… In order to explore the optimal transfection condition, we … F), and found that high transfection
efficiency was achieved at a N/… for a fully effective anti-tumor immunotherapy, which might be …

… We then formulate the optimal control problem in Section 3 and give a theoretical analysis of
… Piccoli, Optimal control in a model of dendritic cell transfection cancer immunotherapy, Bul. …

… is typically associated with T cell function, we demonstrate here that dendritic cells (DCs) are
… Briefly, cells were transfected in T75 flasks using 5 μg of DNA for single transfections and 5 …

… Immunotherapy offers a plethora of different treatment possibilities. Among these, dendritic
cell (DC)-based cancer … benefits of EP over other transfection methods as well as giving an …

… clinical outcomes of immunotherapy. By transfecting genes of relevant cytokines into tumor
cells, we … We thereby demonstrate an effective strategy for improving tumor immunotherapy. …

… T cells with DCs transfected with tumor mRNA, T cells with … primary and the recall T-cell
response are triggered (Bullock … model accounting for DC-based anti-cancer immunotherapy. …

… cells and their application in cancer immunotherapy. Next, we will discuss the physical
transfection … electroporation, sonoporation, nanowire poration and cell squeezing ( Figure 1 ). We …

… DC vaccination is a novel concept and leading strategies of cancer immunotherapy, and …
Transfection of DCs with TAA-encoding vectors or tumor cells-extracted RNA [115]. Transfected …

… Dendritic cell therapy is an immunotherapy that capitalizes on the critical role … Piccoli, Optimal
control in a model of dendritic cell transfection cancer immunotherapy, Bull. Math. Biol., 68 (…