Fate and state of vascular smooth muscle cells in atherosclerosis

JM Miano, EA Fisher, MW Majesky - Circulation, 2021 - Am Heart Assoc
Vascular smooth muscle cells (VSMCs) have long been … Innovative technologies in cell
lineage tracing, single-cell RNA … state independent of the embryological origin of VSMCs. …

Vascular smooth muscle cells in atherosclerosis: time for a re-assessment

MOJ Grootaert, MR Bennett - Cardiovascular research, 2021 - academic.oup.com
… , 37 and carotid 38 , 39 artery lesions and the transcriptomic cell clusters of advanced human
differential developmental origin 38 and to those of mouse brachiocephalic artery plaques. …

How vascular smooth muscle cell phenotype switching contributes to vascular disease

G Cao, X Xuan, J Hu, R Zhang, H Jin… - Cell Communication and …, 2022 - Springer
Vascular smooth muscle cells (VSMCs) are the most abundant cell in vessels. Earlier …
osteogenic transition and vascular calcification given the background of hyperphosphatemia [40]. …

An update on the phenotypic switching of vascular smooth muscle cells in the pathogenesis of atherosclerosis

F Zhang, X Guo, Y Xia, L Mao - Cellular and Molecular Life Sciences, 2022 - Springer
Vascular smooth muscle cells (VSMCs) are involved in phenotypic switching in
atherosclerosis. This switching is characterized by VSMC dedifferentiation, migration, and …

Role of vascular smooth muscle cell plasticity and interactions in vessel wall inflammation

V Sorokin, K Vickneson, T Kofidis, CC Woo… - Frontiers in …, 2020 - frontiersin.org
… (SMC) identification and fate tracing is complex is related to the differences in the embryonic
origin of VSMCs. For example, VSMCs in coronary arteries are derived from the epicardium, …

The role of vascular smooth muscle cells in the development of aortic aneurysms and dissections

KB Rombouts, TAR van Merrienboer… - European journal of …, 2022 - Wiley Online Library
Vascular smooth muscle cells (vSMC) are the predominant cell type within the aortic wall
and dysregulation of vSMC functions contributes to AA and AD development and progression. …

A Notch3-marked subpopulation of vascular smooth muscle cells is the cell of origin for occlusive pulmonary vascular lesions

LC Steffes, AA Froistad, A Andruska, M Boehm… - Circulation, 2020 - Am Heart Assoc
… D and E, Daily 5-Ethynyl-2-deoxyuridine (EdU) administration during the first 2 weeks of
HDM exposure shows cell division among vascular smooth muscle cells in media (arrowheads), …

Six shades of vascular smooth muscle cells illuminated by KLF4 (Krüppel-Like Factor 4)

C Yap, A Mieremet, CJM de Vries, D Micha… - … , and vascular biology, 2021 - Am Heart Assoc
Multiple layers of vascular smooth muscle cells (vSMCs) are present in blood vessels forming
the media of the vessel wall. vSMCs provide a vessel wall structure, enabling it to contract …

[HTML][HTML] Metabolism of vascular smooth muscle cells in vascular diseases

J Shi, Y Yang, A Cheng, G Xu… - American Journal of …, 2020 - journals.physiology.org
artery smooth muscle cells (PASMCs) and human aortic smooth muscle cells (HAoSMCs);
the differences … , the reserve capacity is a potent supply source of energy, thereby avoids the “…

Arterial Sca1+ vascular stem cells generate de novo smooth muscle for artery repair and regeneration

J Tang, H Wang, X Huang, F Li, H Zhu, Y Li, L He… - Cell stem cell, 2020 - cell.com
… layer of smooth muscle that constitutes the majority of the cells of the vessel wall. Vascular
smooth muscle cells (SMCs) in different segments of arteries have several distinct origins in …