PPARs-orchestrated metabolic homeostasis in the adipose tissue

C Sun, S Mao, S Chen, W Zhang, C Liu - International journal of …, 2021 - mdpi.com
… mice, adipose tissue-specific loss of PPARγ led to critical atrophy of adipose tissue and
was … mutants in human subjects also supports the important role of PPARγ in adipose tissue

Increase in leptin and PPAR-γ gene expression in lipedema adipocytes differentiated in vitro from adipose-derived stem cells

S Al-Ghadban, ZT Diaz, HJ Singer, KB Mert… - Cells, 2020 - mdpi.com
… Our team and others have shown that lipedema adipose tissue is a highly vascularized and
fibrotic tissue with an increase in blood vessels, infiltrating macrophages and hypertrophic …

[HTML][HTML] PPARγ and PPARα synergize to induce robust browning of white fat in vivo

T Kroon, M Harms, S Maurer, L Bonnet… - Molecular …, 2020 - Elsevier
… and subsequent synergistic effect with PPARγ activation in adipose tissues. Indeed, tesaglitazar
… correlated with Ucp1 levels in adipose tissues in all in vivo studies performed with dual …

In vitro and ex vivo models of adipocytes

J Dufau, JX Shen, M Couchet… - … of Physiology-Cell …, 2021 - journals.physiology.org
… It may take place during adulthood, allowing adipocyte turnover and adipose tissue
Whereas the requirement of PPARγ agonists is mandatory for optimal differentiation of human …

Enhanced 3T3-L1 differentiation into adipocytes by pioglitazone pharmacological activation of peroxisome proliferator activated receptor-gamma (PPAR-γ)

C Teixeira, AP Sousa, I Santos, AC Rocha, I Alencastre… - Biology, 2022 - mdpi.com
… to adipocyte differentiation and lipid storage in adipose tissue and that increase insulin sensitivity
in peripheral tissues … to adipocyte differentiation and lipid storage in adipose tissue and …

[HTML][HTML] Peroxisome proliferator-activated receptor γ in white and brown adipocyte regulation and differentiation

WU Hui, LI Xiaohua, S Chunyan - Physiological Research, 2020 - ncbi.nlm.nih.gov
… proliferator-activated receptor γ (PPARγ) binds to the target … the differentiation of preadipocytes
in the adipose tissue, and … of regulating PPARγ on adipocyte differentiation are reviewed. …

ALDH1A1 inhibits chicken preadipocytes' proliferation and differentiation via the PPARγ pathway in vitro and in vivo

J Zhang, B Cai, M Ma, W Luo, Z Zhang… - International Journal of …, 2020 - mdpi.com
… a brown adipose tissue-like transcriptional program in white adipose tissue, promoting …
Moreover, researchers found that PPARγ expression was significantly suppressed by zinc-…

Macrophages inhibit adipogenic differentiation of adipose tissue derived mesenchymal stem/stromal cells by producing pro-inflammatory cytokines

H Ma, Y Li, L Song, R Liu, X Li, Q Shang, Y Wang… - Cell & bioscience, 2020 - Springer
adipocyte differentiation of hADSC in vitro, whether the findings can be translated to the
physiological and pathological conditions in vivo … interact with ADSCs in vivo also needs to be …

Triphenyl phosphate is a selective PPARγ modulator that does not induce brite adipogenesis in vitro and in vivo

S Kim, N Rabhi, BC Blum, R Hekman, K Wynne… - Archives of …, 2020 - Springer
vivo and in vitro (3T3-L1 cells and primary human preadipocytes) models, we demonstrate
that unlike classical PPARγ … We next examined the inguinal adipose tissue (IWAT) morphology…

The role of ADP-ribose metabolism in metabolic regulation, adipose tissue differentiation, and metabolism

M Szántó, P Bai - Genes & Development, 2020 - genesdev.cshlp.org
… also characterizes the in vivo differentiation of adipocytes. After … droplets (in vitro differentiated
adipocytes are multilocular), … are PPARγ-dependent and encompass all processes needed