PPARγ acetylation orchestrates adipose plasticity and metabolic rhythms
Y He, A B'nai Taub, L Yu, Y Yao, R Zhang… - Advanced …, 2023 - Wiley Online Library
… function, and the sensitive nature and importance of PTMs, we hypothesized that the acetylation
of PPARγ is dynamically regulated in adipose tissue to affect metabolic rhythm. To test it, …
of PPARγ is dynamically regulated in adipose tissue to affect metabolic rhythm. To test it, …
[HTML][HTML] Dehydroabietic acid alleviates high fat diet-induced insulin resistance and hepatic steatosis through dual activation of PPAR-γ and PPAR-α
Z Xie, G Gao, H Wang, E Li, Y Yuan, J Xu… - Biomedicine & …, 2020 - Elsevier
… remodel adipose tissue resulting in adipocyte hypertrophy … On the other hand, such
newly differentiated adipocytes are … cytokine expression via the PPARγ/PTEN pathways [31]. …
newly differentiated adipocytes are … cytokine expression via the PPARγ/PTEN pathways [31]. …
[HTML][HTML] Cannabidiol promotes adipogenesis of human and mouse mesenchymal stem cells via PPARγ by inducing lipogenesis but not lipolysis
RC Chang, CS Thangavelu, EM Joloya, A Kuo… - Biochemical …, 2022 - Elsevier
… of CBD could lead to increased accumulation of white adipose tissue. … PPARγ, we tested
whether CBD could antagonize PPARγ activation by ROSI or if ROSI could antagonize PPARγ …
whether CBD could antagonize PPARγ activation by ROSI or if ROSI could antagonize PPARγ …
PPARγ transcription deficiency exacerbates high-fat diet-induced adipocyte hypertrophy and insulin resistance in mice
F Guo, S Xu, Y Zhu, X Zheng, Y Lu, J Tu, Y He… - Frontiers in …, 2020 - frontiersin.org
… levels of PPARγ target genes in the adipose tissue. As the … of PPARγ we tested were
significantly decreased in PPARγ … the expression PPARγ target genes in WT mice; in PPARγ 3RA…
significantly decreased in PPARγ … the expression PPARγ target genes in WT mice; in PPARγ 3RA…
TAZ is a negative regulator of PPARγ activity in adipocytes and TAZ deletion improves insulin sensitivity and glucose tolerance
D El Ouarrat, R Isaac, YS Lee, J Wollam, D Lackey… - Cell metabolism, 2020 - cell.com
… PPARγ response genes are upregulated in adipose tissue from TAZ AKO mice and adipose
tissue inflammation was also decreased. In vitro and in vivo mechanistic studies revealed …
tissue inflammation was also decreased. In vitro and in vivo mechanistic studies revealed …
[HTML][HTML] Metabolic regulation by PPARγ is required for IL-33-mediated activation of ILC2s in lung and adipose tissue
T Fali, T Aychek, M Ferhat, JY Jouzeau… - Mucosal …, 2021 - Elsevier
… Here, we demonstrate that PPARγ is highly expressed in ILC2s, and is required for their
proliferation and effector functions through the control of energy metabolism and the …
proliferation and effector functions through the control of energy metabolism and the …
[HTML][HTML] Reduction in endoplasmic reticulum stress activates beige adipocytes differentiation and alleviates high fat diet-induced metabolic phenotypes
JM Lee, S Park, D Lee, RP Ginting, MR Lee… - … et Biophysica Acta (BBA …, 2021 - Elsevier
… ) was significantly enhanced in inguinal white adipose tissue (iWAT) and high fat diet (HFD)-…
location for physical interaction between the essential transcription factors, PPARγ, C/EBPβ, …
location for physical interaction between the essential transcription factors, PPARγ, C/EBPβ, …
Distinct shades of adipocytes control the metabolic roles of adipose tissues: from their origins to their relevance for medical applications
… tissue. We will also introduce new trends pointing out a rational targeting of adipose tissue
… such as peroxisome proliferator-activated receptor-γ (PPARγ), or protein kinase B (AKT2) as …
… such as peroxisome proliferator-activated receptor-γ (PPARγ), or protein kinase B (AKT2) as …
Cdo1 promotes PPARγ-mediated adipose tissue lipolysis in male mice
YY Guo, BY Li, G Xiao, Y Liu, L Guo, QQ Tang - Nature Metabolism, 2022 - nature.com
… γ (PPARγ) is enriched in adipose tissue. It serves as a key regulator in adipocyte differentiation,
… Cdo1 mRNA levels are predominantly high in adipose tissue and the liver 21 . Global …
… Cdo1 mRNA levels are predominantly high in adipose tissue and the liver 21 . Global …
[HTML][HTML] … (PPARγ) activation and metabolism disturbance induced by bisphenol A and its replacement analog bisphenol S using in vitro macrophages and in vivo …
P Gao, L Wang, N Yang, J Wen, M Zhao, G Su… - Environment …, 2020 - Elsevier
… to activate PPARγ, we firstly conducted PPARγ luciferase reporter assay containing a PPARγ
… macrophages in adipose tissue, which are referred as adipose tissue macrophage (ATM), …
… macrophages in adipose tissue, which are referred as adipose tissue macrophage (ATM), …