Regulatory mechanisms of the early phase of white adipocyte differentiation: An overview

M Audano, S Pedretti, D Caruso, M Crestani… - Cellular and molecular …, 2022 - Springer
… brown adipose tissues. Adipogenesis is a process leading to newly differentiated adipocytes
… Specifically, if PPARγ-1 activity is still poorly understood, PPARγ-2 has been demonstrated …

… ligand‐binding pocket in peroxisome proliferator‐activated receptor gamma and its correlated selective agonist for promoting beige adipocyte differentiation

Q Tian, M Wang, X Wang, Z Lei, O Ahmad, D Chen… - MedComm, 2024 - Wiley Online Library
… gamma (PPARγ) is highly expressed in white adipose tissue (… , PPARγ is indispensable for
adipocyte differentiation and … -activated PPARγ and promoted beige-adipocyte differentiation

The potential to fight obesity with adipogenesis modulating compounds

J Zhao, A Zhou, W Qi - International journal of molecular sciences, 2022 - mdpi.com
vivo studies have suggested that the various adipose tissue … that AICAR could inhibit
the in vitro differentiation of 3T3-L1, … PPARγ, and inhibit early clonal expansion of pre-adipocytes

3D adipose tissue culture links the organotypic microenvironment to improved adipogenesis

JX Shen, M Couchet, J Dufau… - Advanced …, 2021 - Wiley Online Library
essential role of PPARγ in adipogenesis, we first focused on the expression of all experimentally
validated direct PPARγ … and genes not expressed in human adipocytes, 39 genes (89%…

Dexamethasone primes adipocyte precursor cells for differentiation by enhancing adipogenic competency

MG Zubiría, AP Giordano, SE Gambaro, A Alzamendi… - Life Sciences, 2020 - Elsevier
… (SVF) cells from retroperitoneal adipose tissue (RPAT) were … , we measured PPARγ protein
level and quantified PPARγ + … in nuclear protein level of PPARγ (Nuclear Fluorescence …

[HTML][HTML] Novel insights into regulators and functional modulators of adipogenesis

HY Kim, HJ Jang, S Muthamil, UC Shin, JH Lyu… - Biomedicine & …, 2024 - Elsevier
… As a long-term consequence, failure of adipocyte renewal and fat tissue atrophy can induce
… that PPARγ is essential for adipocyte maturation and function in both in vitro and in vivo

Regulatory microRNAs in brown, brite and white adipose tissue

S Gharanei, K Shabir, JE Brown, MO Weickert… - Cells, 2020 - mdpi.com
… This regulation of gene expression by miRNAs in adipose tissue (AT) can impact on the …
types of adipocytes which exist in mammals, ie, white adipocytes (white AT; WAT), brown …

Transcriptional factors of thermogenic adipocyte development and generation of brown and beige adipocytes from stem cells

TT Van Nguyen, VV Vu, PV Pham - Stem cell reviews and reports, 2020 - Springer
… regions of white adipose tissue (WAT), BAT and beige adipose tissue in rodents and …
needed to be investigated, the function of PPARγ in inducing both brown adipocyte differentiation

PPARγ enhanced Adiponectin polymerization and trafficking by promoting RUVBL2 expression during adipogenic differentiation

D Zhu, L Xu, X Wei, B Xia, Y Gong, Q Li, X Chen - Gene, 2021 - Elsevier
… Our present study might provide valuable information for regulating adipose tissue
development and exploiting effective therapeutic strategies against obesity-related metabolic …

The proliferation and differentiation of adipose-derived stem cells in neovascularization and angiogenesis

G Hutchings, K Janowicz, L Moncrieff… - International journal of …, 2020 - mdpi.com
adipose tissue is made up of fully differentiated adipocytes. The remaining two thirds contain
large numbers of preadipocytes, which allows adipose tissue … of the PPARγ transcriptional …