Glucosylceramide synthase regulates adipo‐osteogenic differentiation through synergistic activation of PPARγ with GlcCer

HJ Jang, S Lim, JM Kim, S Yoon, CY Lee… - The FASEB …, 2020 - Wiley Online Library
… on PPARγ activation, we performed the in vitro PPARγ binding assay to PPRE by using a
PPARγ … and adipose tissue through inhibition of the PPARγ activity and adipogenic potency of …

Genipin guides and sustains the polarization of macrophages to the pro-regenerative M2 subtype via activation of the pSTAT6-PPAR-gamma pathway

I Isali, P McClellan, E Shankar, S Gupta, M Jain… - Acta biomaterialia, 2021 - Elsevier
adipose tissue and adrenal glands. It is expressed moderately in macrophages, but its
expression can also be prompted by IL-4 and IL-13, which shows a probable role for the nuclear …

Phthalate exposure causes browning-like effects on adipocytes in vitro and in vivo

JW Hsu, CY Nien, SC Yeh, FY Tsai, HW Chen… - Food and Chemical …, 2020 - Elsevier
differentiation, lipid synthesis, carbohydrate uptake, and WAT/brown adipose tissue (BAT)
quantity. PPARγ and NR4A1 were predicted as the top two upstream regulators in …

[HTML][HTML] The intricate role of p53 in adipocyte differentiation and function

YK Lee, YS Chung, JH Lee, JM Chun, JH Park - Cells, 2020 - mdpi.com
… Although all adipose tissues are derived from mesenchymal … of Pparγ and its coactivator
PPARγ coactivator1 alpha (Ppargc1a or Pgc-1α) [32,34,43]. Knockdown of p53 in differentiated

PPARγ-induced upregulation of subcutaneous fat adiponectin secretion, glyceroneogenesis and BCAA oxidation requires mTORC1 activity

ML Andrade, GR Gilio, LA Perandini, AS Peixoto… - … et Biophysica Acta (BBA …, 2021 - Elsevier
… , a co-partner and facilitator of PPARγ. In conclusion, mTORC1 and PPARγ are essential
partners involved in the regulation of subcutaneous adipose tissue adiponectin production and …

[HTML][HTML] Inflammatory bowel disease: new insights into the interplay between environmental factors and PPARγ

G Caioni, A Viscido, M d'Angelo, G Panella… - International Journal of …, 2021 - mdpi.com
… between chemical compounds and PPARγ. In particular, a … influence PPARγ and indirectly
the homeostasis of adipose tissueAdipose tissue is no longer considered mere storage of fat, …

[HTML][HTML] The action of vitamin D in adipose tissue: is there the link between vitamin D deficiency and adipose tissue-related metabolic disorders?

I Szymczak-Pajor, K Miazek, A Selmi… - International Journal of …, 2022 - mdpi.com
… of fatty acids secreted by macrophages and adipose tissue that translocates ligands to the
nuclear receptor of PPARγ … Transcription factors, including PPARγ and C/EBPα, activate the …

[HTML][HTML] In vivo liposomal delivery of PPARα/γ dual agonist tesaglitazar in a model of obesity enriches macrophage targeting and limits liver and kidney drug effects

V Osinski, DK Bauknight, SSK Dasa, MJ Harms… - Theranostics, 2020 - ncbi.nlm.nih.gov
… effects on adipose tissue macrophage populations in vivo. … of PPARγ in macrophages or
in vivo treatment with a PPARγ … of adipose tissue macrophage (ATM) populations attenuates …

PPAR‐γ signalling as a key mediator of human hair follicle physiology and pathology

Y Ramot, M Bertolini, M Boboljova… - Experimental …, 2020 - Wiley Online Library
adipose tissue. It is activated by endogenous ligands, including carbaprostacyclin, unsaturated
fatty … in sebocytes and adipose tissue, but also in many different other tissues and organs.…

Isorhapontigenin improves diabetes in mice via regulating the activity and stability of PPARγ in adipocytes

XY Chu, SZ Yang, MQ Zhu, DY Zhang… - Journal of agricultural …, 2020 - ACS Publications
… Mechanistically, we showed that isorhapontigenin improves insulin sensitivity in adipose
tissue by enhancing the activity and stability of PPARγ though decreasing its inhibitory …