… of EZH2 on GATA4 transcriptional activity, we overexpressed … PRC2 interacts with GATA4
and regulates lysine methylation… transcriptional repression of FAS by PRC2, partly through the …

… at some repressed genes in erythroid and megakaryocytic cells, which suggests that PRC2
is involved in … Endothelial genes normally repressed by GATA4 are upregulated in mutated …

… for lysine methylation and serve as the catalytic subunit of PRC2. … PRC2 core complex,
which reciprocally enhances the binding of PCLs to CGI DNAs in pairs for gene repression…

… in Gata4 Prx-cKO mice. We suggest that WNT signalosome activity in MSCs requires Gata4
and … We have also shown that GATA4 represses RANKL gene expression in osteoblasts. …

… by DNA methylation and transcriptional activity. Accordingly, inhibition of transcription induced
global recruitment of PRC2 to … A PRC2 methylates and represses GATA4 activity, whereas …

… , thereby facilitating gene repression in ESCs (21,23). This is … We show that Tet1 facilitates
recruitment of PRC2 (for H3K27 … loss of its catalytic activity increases global DNA methylation, …

… These super-enhancers have high transcriptional activity and regulate essential pluripotent
… that BACH1 repressed the transcription of mesendodermal genes via recruiting PRC2 to …

… interacts with FOG2, a direct modulator of GATA4 transcriptional activity. One target of …
identified PRC2 methylation of nonhistone targets as an additional mechanism of gene repression. …

… is thought to repress gene expression in a PRC2dependent … expressed Hox13 paralogs
directly repress multiple Hox genes … of histone methylation marks deposited by PRC2 activity. …

… PRC2 comprises enhancer of zeste 2 (EZH2) or its close … -1 and EZH2 directly compete to
bind to GATA-4 during the … EZH2 can methylate GATA-4 and repress its transcriptional activity […