Polygenic risk scores shed light on the relationship between schizophrenia and cognitive functioning: review and meta-analysis

J Mallet, Y Le Strat, C Dubertret, P Gorwood - Journal of clinical medicine, 2020 - mdpi.com
… links between SZ and cognitive functions in population-based … meta-analysis therefore argues
against universal pleiotropy … [22], with a difference for intelligence between childhood (h 2 …

[HTML][HTML] Dissecting Schizophrenia Biology Using Pleiotropy with Cognitive Genomics

U Bhattacharyya, J John, T Lencz, M Lam - medRxiv, 2024 - ncbi.nlm.nih.gov
… task performance) to differentiate two subsets of illness-… Our pleiotropic meta-analysis of
schizophrenia and the two … studies to understand the role of protein translation in schizophrenia. …

89. PLEIOTROPIC META-ANALYSIS WITH COGNITIVE ENDOPHENOTYPES DIFFERENTIATES NEURODEVELOPMENTAL, SYNAPTIC, AND APOPTOTIC …

J John, U Bhattacharyya, T Lencz, M Lam - European …, 2023 - Elsevier
… These results expand on our previous study of cognitive endophenotypic pleiotropy in
schizophrenia, … of gene expression in schizophrenia, and suggest distinct roles for concordant and …

Collective genomic segments with differential pleiotropic patterns between cognitive dimensions and psychopathology

M Lam, CY Chen, WD Hill, C Xia, R Tian… - Nature …, 2022 - nature.com
… We have recently reported the largest GWAS meta-analysis for … , in which we leveraged
cognitive pleiotropy to differentiate early … In the current report, schizophrenia and bipolar disorder …

[HTML][HTML] Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking

EC Johnson, I Austin-Zimmerman, HHA Thorpe… - medRxiv, 2024 - ncbi.nlm.nih.gov
pleiotropy and causal mechanisms may play a role in the … GWAS, due to the relative difference
in discovery power between the … from a GWAS meta-analysis of schizophrenia in African …

Involvement of the long intergenic non-coding RNA LINC00461 in schizophrenia

S Rao, L Tian, H Cao, A Baranova, F Zhang - BMC psychiatry, 2022 - Springer
… This meta-analysis showed that rs410216 was significantly … − 12.10; β represents the difference
in intracranial volume per … meta-analysis has identified LINC00461 as a pleiotropic gene …

Integrative analysis of genome-wide association studies identifies novel loci associated with neuropsychiatric disorders

X Yao, JT Glessner, J Li, X Qi, X Hou, C Zhu… - Translational …, 2021 - nature.com
… We performed multi-trait joint analyses and meta-analysis … by PGC further reported 109
pleiotropic loci, including 23 … −3 ) and it did not show a significant difference from 1 (P = 0.0735), …

Recent natural selection conferred protection against schizophrenia by non-antagonistic pleiotropy

J González-Peñas, L De Hoyos, CM Díaz-Caneja… - Scientific Reports, 2023 - nature.com
… with other mental and somatic conditions and the pleiotropic … acted to differentiate human
populations across schizophreniafunctions as well as more pleiotropic associations relative to …

The relationship between immune and cognitive dysfunction in mood and psychotic disorder: a systematic review and a meta-analysis

M Morrens, C Overloop, V Coppens, E Loots… - Molecular …, 2022 - nature.com
… produced by a variety of cells and have a myriad of pleiotropic effects in the brain [146,
147], … factor in schizophrenia: a systematic review and meta-analysis. Int J Mol Sci 2016;17:1766. …

Genetic variation, brain, and intelligence differences

IJ Deary, SR Cox, WD Hill - Molecular psychiatry, 2022 - nature.com
… to vertical pleiotropy, horizontal pleiotropy, or spurious pleiotropy, … A complementary
explanation of some of the difference in … A meta-analysis of data from over 148 studies across …