… qPCR and infectivity assays in challenging matrices such as … protein in a cell-based assay.
Different companies are using … These cell-based assays are routinely used to measure the …

… This article focuses on cell-based assays designed to detect anti-AAV antibodies that may
… , although collection of such samples may be challenging. Whereas it is feasible to collect …

… current applications of human cell-based in vitro methods. Unsolved problems and emerging
… Replacement of animal experiments is motivated by ethical and scientific concerns and …

… Cell-based assays are used throughout all the stages of drug discovery: target identification
and validation, … Pending challenges in this area include cell growth inside droplets and the …

… We were able to detect the human-specific teratogenicity of … than thalidomide in our assay.
We conclude that the PluriBeat … PluriBeat assay, since they possess no ethical concerns and …

… One of the biggest challenges in the development and … information relative to conventional
HTS cell-based assays. … to safety issues represents a huge liability for the drug development …

… As cell-based assays are the focus of this review we concentrated on these assays for the …
not only to address practical issues such as throughput and cost concerns but also to consider …

… to (1) challenges and opportunities for using PBBM to assess the … Cell-based permeability
assays should be scaled to a … When optimizing parameters, identifiability issues arise if the …

… In 2018, the NIH-led Discovery and Validation of Biomarkers to Develop Non-Addictive … to
discuss progress, challenges, gaps and ideas to facilitate the development of biomarkers and …

… based on human tissues. In vitro, cell-based assays are critical tools in drug development, …
with clear and precise outputs and easy incorporation of human cells and tissues [14,15]. Also…