[HTML][HTML] Genistein inhibits angiogenesis developed during rheumatoid arthritis through the IL-6/JAK2/STAT3/VEGF signalling pathway

WX Cheng, H Huang, JH Chen, TT Zhang… - Journal of orthopaedic …, 2020 - Elsevier
… in vascular endothelial growth factor (VEGF) expression and angiogenesis induced by the
inflammatory environment of RA. … Upregulation of various proinflammatory and angiogenic …

Angiogenesis as a potential treatment strategy for rheumatoid arthritis

Y Wang, H Wu, R Deng - European journal of pharmacology, 2021 - Elsevier
vascular endothelial growth factor family (VEGF), transforming growth factor family (TGF),
platelet-derived growth factor … of RA patients produce a variety of pro-inflammatory mediators, …

Cytokine networks in the pathogenesis of rheumatoid arthritis

N Kondo, T Kuroda, D Kobayashi - International journal of molecular …, 2021 - mdpi.com
… process in RA pathogenesis, and this can occur via the action of proinflammatory cytokines,
… GM-CSF is a well-known hemopoietic growth factor produced mainly by T cells and stromal …

Molecular and cellular pathways contributing to joint damage in rheumatoid arthritis

Q Fang, C Zhou, KS Nandakumar - Mediators of inflammation, 2020 - Wiley Online Library
… by the proinflammatory INHBA gene is significantly elevated in RARA-FLS also secretes
many proangiogenic factors like fibroblast growth factor, vascular endothelial growth factor

Role of adiponectin in the pathogenesis of rheumatoid arthritis

K Szumilas, P Szumilas… - International journal of …, 2020 - mdpi.com
… anti-inflammatory and pro-inflammatory properties. Several … important pro-inflammatory
role in the pathophysiology of RA … the production of vascular endothelial growth factor (VEGF) …

Anti-angiogenic effect of Shikonin in rheumatoid arthritis by downregulating PI3K/AKT and MAPKs signaling pathways

C Liu, L He, J Wang, Q Wang, C Sun, Y Li, K Jia… - Journal of …, 2020 - Elsevier
… various mediators such as vascular endothelial growth factor (VEGF), tumor necrosis factor
(TNF-α… Further, it inhibited IL-6, IL-8, TNF, IL-12 and IL-17A, which is called proinflammatory

Blocking GM-CSF receptor α with mavrilimumab reduces infiltrating cells, pro-inflammatory markers and neoangiogenesis in ex vivo cultured arteries from patients …

M Corbera-Bellalta, R Alba-Rovira… - … of the rheumatic …, 2022 - ard.bmj.com
… . Binding to the extracellular matrix and proteolytic processing: two key mechanisms
regulating vascular endothelial growth factor action. Mol Biol Cell 2010;21:687–90.doi:10.1091/mbc.…

Resolvin D1 suppresses pannus formation via decreasing connective tissue growth factor caused by upregulation of miRNA-146a-5p in rheumatoid arthritis

W Sun, J Ma, H Zhao, C Xiao, H Zhong, H Ling… - Arthritis Research & …, 2020 - Springer
… expressions of pro-inflammatory cytokines and CTGF in RA FLS During the development of
RA, … The expression profiles of pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) in RA FLS …

Role of the eNOS uncoupling and the nitric oxide metabolic pathway in the pathogenesis of autoimmune rheumatic diseases

A Łuczak, M Madej, A Kasprzyk… - Oxidative Medicine and …, 2020 - Wiley Online Library
… of proinflammatory mediators … vascular endothelial growth factor (VEGF) levels. Both
enhanced NOS activity and reduced superoxide production can be due to the decrease in vascular

Pathogenesis and function of interleukin-35 in rheumatoid arthritis

PL Xin, LF Jie, Q Cheng, DY Bin… - Frontiers in Pharmacology, 2021 - frontiersin.org
… (vascular endothelial growth factor), which is critical in the pannus formation in synovial tissues
and plays an important role in RA (… the expression level of pro-inflammatory cytokines in …