Measuring biological aging in humans: A quest

L Ferrucci, M Gonzalez‐Freire, E Fabbri… - Aging cell, 2020 - Wiley Online Library
… drivers of biological aging. However, reliable and valid assays for their quantification
should be developed before they can be used in human research and in clinical applications. …

A toolkit for quantification of biological age from blood chemistry and organ function test data: BioAge

D Kwon, DW Belsky - GeroScience, 2021 - Springer
… Methods to quantify biological aging are emerging as new measurement tools for …
Publicly available software packages to compute biological aging measurements from DNA …

Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm

DW Belsky, A Caspi, L Arseneault, A Baccarelli… - Elife, 2020 - elifesciences.org
… were associated with faster DunedinPoAm in young adults in the E-Risk Study To test if
DunedinPoAm indicated faster aging in young people with histories of exposure thought to …

Association of blood chemistry quantifications of biological aging with disability and mortality in older adults

DC Parker, BN Bartlett, HJ Cohen… - The Journals of …, 2020 - academic.oup.com
adults in the United States (N = 1,374, age range = 71–102, 35% male, 52% African American).
We quantified biological aging … methods to quantify biological aging in older adults, but …

Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy

ML Elliott, A Caspi, RM Houts, A Ambler, JM Broadbent… - Nature aging, 2021 - nature.com
… , dental and pulmonary systems, and quantified age-related decline shared … biological
aging in the Dunedin Study the ‘Pace of Aging’. In a 2015 article, we quantified the Pace of Aging

Measuring biological age using omics data

J Rutledge, H Oh, T Wyss-Coray - Nature Reviews Genetics, 2022 - nature.com
… to quantify a composite rate of biological ageing 74 . The DunedinPoAm DNAm clock was
then trained with standard methods to estimate this rate with CpG methylation. This clock had …

Determination of biological age: geriatric assessment vs biological biomarkers

LWM Diebel, K Rockwood - Current oncology reports, 2021 - Springer
… Biomarkers from various levels of the biological aging process are improving in accuracy,
with the potential to identify aberrant aging trajectories before the onset of clinically manifest …

Brain-age in midlife is associated with accelerated biological aging and cognitive decline in a longitudinal birth cohort

ML Elliott, DW Belsky, AR Knodt, D Ireland… - Molecular …, 2021 - nature.com
… By quantifying each person’s personal pace of biological aging, we were able to
demonstrate that Study members with older brainAGE had experienced at least two decades of …

Socioeconomic disadvantage and the pace of biological aging in children

L Raffington, DW Belsky, M Kothari, M Malanchini… - …, 2021 - publications.aap.org
… , measures are needed that can quantify early acceleration of biological aging in childhood.
… to test how aging processes may be accelerated in at-risk young people and if and how …

Biological aging in childhood and adolescence following experiences of threat and deprivation: A systematic review and meta-analysis.

NL Colich, ML Rosen, ES Williams… - Psychological …, 2020 - psycnet.apa.org
… with biological aging vary according to the nature of adversity experienced. ELA overall
was … CpG sites) to quantify biological age independent from chronological age (DNAm age) …