[HTML][HTML] Distinct biological ages of organs and systems identified from a multi-omics study
… Therefore, in the present study we established a cohort of young adults with multi-omics data…
The R-squared was the coefficient of determination calculated from linear regression model. …
The R-squared was the coefficient of determination calculated from linear regression model. …
[HTML][HTML] Biohorology and biomarkers of aging: Current state-of-the-art, challenges and opportunities
… theory of aging has been difficult due to the inability to properly quantify and define aging. …
Without general agreement as to what constitutes aging and biological age (BA), and how …
Without general agreement as to what constitutes aging and biological age (BA), and how …
Diet modulates brain network stability, a biomarker for brain aging, in young adults
LR Mujica-Parodi, A Amgalan… - Proceedings of the …, 2020 - National Acad Sciences
… We quantified the stability of brain networks in two complementary ways. To measure gross
difference, we calculated total instability, defined as the (scalar) norm of difference in the …
difference, we calculated total instability, defined as the (scalar) norm of difference in the …
Epigenetic measures of ageing predict the prevalence and incidence of leading causes of death and disease burden
… age exhibit disparate rates of biological ageing and susceptibilities to common morbidities
and mortality. Differential patterns of biological ageing among individuals may be exploited to …
and mortality. Differential patterns of biological ageing among individuals may be exploited to …
[HTML][HTML] Early stem cell aging in the mature brain
… Aging has been historically investigated in chronological terms, with the majority of studies
comparing young and old organisms. Yet, approaches to prevent aging at younger ages have …
comparing young and old organisms. Yet, approaches to prevent aging at younger ages have …
An integrative study of five biological clocks in somatic and mental health
… biological aging, this study aimed to examine (1) the intercorrelations between biological
aging … ; (2) the relationships between different biological aging indicators with both somatic and …
aging … ; (2) the relationships between different biological aging indicators with both somatic and …
Molecular damage in aging
… has in aging and aging-related outcomes requires the ability to simultaneously quantify many
… with chronological and biological age, aging-related diseases, healthspan and longevity. …
… with chronological and biological age, aging-related diseases, healthspan and longevity. …
[HTML][HTML] A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration
L Oblak, J van der Zaag, AT Higgins-Chen… - Ageing research …, 2021 - Elsevier
… Aging involves a diverse set of biological changes accumulating over time that leads to … to
quantify biological aging, in order to investigate determinants that modify the rate of aging and …
quantify biological aging, in order to investigate determinants that modify the rate of aging and …
A complex systems approach to aging biology
… of aging. We present key examples at scales ranging from sub-organismal biology to …
geriatrics, outlining how this approach can potentially enrich our understanding of aging. …
geriatrics, outlining how this approach can potentially enrich our understanding of aging. …
DNA methylation clocks and their predictive capacity for aging phenotypes and healthspan
T Bergsma, E Rogaeva - Neuroscience insights, 2020 - journals.sagepub.com
… represent fundamental aging processes, methods to measure biological aging have been
… to slow down biological aging and extend healthspan. A reliable measure of biological age …
… to slow down biological aging and extend healthspan. A reliable measure of biological age …