SARS-CoV-2: a storm is raging

SF Pedersen, YC Ho - The Journal of clinical investigation, 2020 - Am Soc Clin Investig
The pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this …

[HTML][HTML] Metformin and SARS-CoV-2: mechanistic lessons on air pollution to weather the cytokine/thrombotic storm in COVID-19

JA Menendez - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
… to SARS-CoV-2 infection. By restraining the raging of cytokine and thrombotic-like storms,
two of the leading causes of morbidity and mortality in SARS-CoV-2 infection, metformin …

Targeting RAGE to prevent SARS-CoV-2-mediated multiple organ failure: Hypotheses and perspectives

S Chiappalupi, L Salvadori, A Vukasinovic, R Donato… - Life Sciences, 2021 - Elsevier
… The disruption of microcapillary integrity causes the entry in the bloodstream of a cytokine
storm and RAGE ligands, resulting in widespread inflammation and Ang II-dependent multi-…

From anti-SARS-CoV-2 immune response to the cytokine storm via molecular mimicry

D Kanduc - Antibodies, 2021 - mdpi.com
… the raging of the cytokine storm that can occur following exposure to SARS-CoV-2. In …
as a potential mechanism in SARS-CoV-2-induced cytokine storms, and highlight the role of …

The four horsemen of a viral Apocalypse: The pathogenesis of SARS-CoV-2 infection (COVID-19)

P Domingo, I Mur, V Pomar, H Corominas… - …, 2020 - thelancet.com
… The inflammatory loop is composed of the exuberant inflammatory response feeding
back until exploding in an actual cytokine storm. Downregulation of the ACE2/Ang-(1–7)/Mas1R …

SARS-CoV-2 causes a different cytokine response compared to other cytokine storm-causing respiratory viruses in severely ill patients

M Olbei, I Hautefort, D Modos, A Treveil… - Frontiers in …, 2021 - frontiersin.org
… by SARS-CoV-2 is different compared to other CRS-causing respiratory viruses, as SARS-CoV-2
by the analyzed viruses highlights a SARS-CoV-2-specific dysregulation of the type-I …

Surviving the storm: cytokine biosignature in SARS-CoV-2 severity prediction

R Ahmad, M Haque - Vaccines, 2022 - mdpi.com
SARS-CoV-2 infection-induced cytokine storm. This article discusses the current findings of
SARS-CoV-2 … other cytokines that result in a cytokine storm, and biomarkers that can act as …

SARS-CoV-2 and COVID-19: from the bench to the bedside

S Romagnoli, A Peris, AR De Gaudio… - Physiological …, 2020 - journals.physiology.org
… Increased levels of IL-6 in severely ill patients (77) have justified the use of treatments that
attenuate the cytokine storm caused by the SARS-CoV-2 infection. The monoclonal antibody …

Bone metabolism in SARS-CoV-2 disease: possible osteoimmunology and gender implications

G Salvio, C Gianfelice, F Firmani, S Lunetti… - Clinical reviews in bone …, 2020 - Springer
… the cytokine storm triggered by contact with SARS-CoV-2. … of RAGE are common in chronic
conditions such as diabetes, cancer, cardiovascular disease, and neurodegeneration. RAGE

[HTML][HTML] SARSCoV2 and the possible connection to ERs, ACE2, and RAGE: Focus on susceptibility factors

RS Stilhano, AJ Costa, MS Nishino, S Shams… - The FASEB …, 2020 - ncbi.nlm.nih.gov
… syndrome coronavirus 2 (SARSCoV2) pandemic has provoked … First, we aim to summarize
the SARSCoV2 infection … Finally, we describe how ERs (estrogen receptors) and RAGE (…