… and psychiatric disorders. Two key findings have emerged: the conditions are polygenic and
genetic overlap is … precision medicine in psychiatry and neurology. Integrating genomic data …

… date have focussed on identifying shared loci or genetic overlap between psychiatric disorders
[6]. … As a parallel analysis, we performed functional annotations and mapped the SNPs to …

… genomic studies regarding pleiotropy and the shared genetic basis of psychiatric disorders.
… across all causal loci (7). In this article, we use r g as an index of polygenic overlap between …

… overlap beyond r g , we provide insights into the unique and shared genetic architectures
underlying psychiatric disorders, with … ” genetic overlap observed across all polygenic traits, or, …

… disease causal proteins are shared with psychiatric disorders… full range of cognitive and
neuropathologic disease severity. … was aliquoted and digested in parallel to make up the global …

… of this polygenic architecture might inform psychiatric nosology, guide … shared features
indicate that the aetiology of schizophrenia overlaps with that of other psychiatric disorders …

… in HC that tend to parallel polygenic risk for MDD might change non… and patients with major
psychiatric disorders. Scientific … risk loci with shared effects on five major psychiatric disorders…

… multifactorial etiology of psychiatric disorders. However, of the hundreds of common variant
loci robustly associated with psychiatric disorders to date, the largest share … generally parallel …

… functional MRI activity and polygenic risk for SCZ and BD [26… of a significant overlap in
sMRI phenotypes along with the … neurological and psychiatric disorders as reported by [2]. …

… There is widespread overlap across major psychiatric disorders, and this is the case at …
more aligned with the shared genetic underpinnings among psychiatric conditions. This could …