The technological landscape and applications of single-cell multi-omics

A Baysoy, Z Bai, R Satija, R Fan - Nature Reviews Molecular Cell …, 2023 - nature.com
single-cell multi-omics technologies have had in cell lineage tracing, tissue-specific and cell-…
technologies together with computational methods will create an integrative framework with …

Methods and applications for single-cell and spatial multi-omics

K Vandereyken, A Sifrim, B Thienpont… - Nature Reviews Genetics, 2023 - nature.com
cell type. However, to develop fundamental understanding of the molecular hierarchy from
genome to phenome in individual cells, multi-omics methodologies at single-cellsingle cells

Singlecell multiomics and its prospective application in cancer biology

A Peng, X Mao, J Zhong, S Fan, Y Hu - Proteomics, 2020 - Wiley Online Library
single-cell multi-omics technologies are summarized and the prospects of their application
… Recently, single-cell multi-omics methods to detect protein and RNA expression of the same …

Integrative methods and practical challenges for single-cell multi-omics

A Ma, A McDermaid, J Xu, Y Chang, Q Ma - Trends in biotechnology, 2020 - cell.com
Applying integrative methods to scMulti-omics data opens a new window into the … computational
methods and tools for integrative analyses. Here, we review these integrative methods

Single-cell multiomics: technologies and data analysis methods

J Lee, DY Hyeon, D Hwang - Experimental & Molecular Medicine, 2020 - nature.com
… By presenting representative applications of these technologies, … the methods for the integrative
analysis of single-cell … relationships (LIGER) 101 and multi-omics factor analysis (MOFA) …

Multi-omics integration in the age of million single-cell data

Z Miao, BD Humphreys, AP McMahon… - Nature Reviews …, 2021 - nature.com
… in computational methods for multi-omics data integration. We first … data-centric view of what
methods might be applied to a … view of what methods one might apply given a particular set …

Gene regulatory network inference in the era of single-cell multi-omics

P Badia-i-Mompel, L Wessels, S Müller-Dott… - Nature Reviews …, 2023 - nature.com
… of single-cell multi-omics technologies has led to the development of novel computational
methods that … We focus on the comparison and classification of methods that use single-cell

[HTML][HTML] Computational strategies for single-cell multi-omics integration

N Adossa, S Khan, KT Rytkönen, LL Elo - Computational and Structural …, 2021 - Elsevier
single-cell multi-omics analytical tools. These tools apply algorithms and analysis methods
that … Many of these methods still remain unexplored in single-cell multi-omics analysis and we …

Advances in bulk and single-cell multi-omics approaches for systems biology and precision medicine

Y Li, L Ma, D Wu, G Chen - Briefings in Bioinformatics, 2021 - academic.oup.com
… and single-cell sequencing technologies and related computational methods for multi-omics
between bulk and single-cell data, and discuss the applications of multi-omics in precision …

Advances in single-cell multi-omics profiling

D Bai, J Peng, C Yi - RSC Chemical Biology, 2021 - pubs.rsc.org
… of a single cell. In this review, we summarize the recent advances of single-cell multi-omics
methods and … bisulfite treatment-based methods, bisulfite-free methods use mild enzymatic or …