… , MA; Lin, CL Restored glial glutamate transporter EAAT2 function as a potential therapeutic
approach for Alzheimer’s disease. Journal of experimental medicine 2015, 212, 319– 32, …

… small molecule translational activator of EAAT2, that is, LO increases EAAT2 expression by
mRNA translation… Parawixin-1 is a neuroprotective compound from Parawixia bistriata spider …

… , glutamate transporter 1 (GLT-1), is responsible for 90% of … , has been shown to promote
activation of EAAT2 translation and … , EAAT2 modulation does appear to have neuroprotective …

… test the neuroprotective abilities of these novel EAAT2 activators in … its transcription, translation,
or glutamate transport efficiency. … mediated glutamate transport enhancement provides a …

… with a small molecule to modulate transporter activity. This … CNS penetrant EAAT2 PAM
holds potential for translation in … compound for neuroprotection would be selective for EAAT2, …

… glutamate release and offer neuroprotection against excitotoxicity, and that their activation
has indirect effects on glutamate transport. … modulation of glutamate transporter EAAT2 seems …

… antagonists capable of being translated into clinical practice … is another neuroprotective
approach that has been explored [57]. … Expressing EAAT2 in MSCs showed greater glutamate …

… This suggests that another coeluting small molecule from the … ± 3%, meaning that our uptake
approach was fully functional. … both l-glutamate transport blocker TBOA and EAAT2 specific …

… glutamate activation, cells become overexcited by glutamate … (MCAO) provided
neuroprotection through a reduction in … and apoptotic factors through EAAT2 upregulation [73]. …

… blockers have failed to translate into clinical stroke treatment. … In this review, we highlight
recent findings on glutamate … We then also summarize potential neuroprotective drugs and …