[HTML][HTML] Prediction of HIV-1 protease cleavage site from octapeptide sequence information using selected classifiers and hybrid descriptors

E Onah, PF Uzor, IC Ugwoke, JU Eze, ST Ugwuanyi… - BMC …, 2022 - Springer
cleavage site of HIV-1 protease can significantly speed up and optimize the drug discovery
process of novel HIV-1 protease … algorithm to assess HIV-1 protease substrate specificity [6]. …

[HTML][HTML] Compositional framework for multitask learning in the identification of cleavage sites of HIV-1 protease

D Singh, DS Sisodia, P Singh - Journal of Biomedical Informatics, 2020 - Elsevier
… learning in the protease cleavage site analysis has certainly … shares knowledge through the
discovered instances. Feature-… the amino acids frequency specific to the peptide sites. Heat …

[HTML][HTML] Predicting HIV-1 protease cleavage sites with positive-unlabeled learning

Z Li, L Hu, Z Tang, C Zhao - Frontiers in Genetics, 2021 - frontiersin.org
… Understanding the substrate specificity of HIV-1 protease … predict substrate sites that are
cleaved by HIV-1 protease, but … to extract useful rules for HIV-1 PR cleavage site prediction, but …

HIV-1 Protease Cleavages

M Abdullah, SA Khawaja… - … Conference on Innovative …, 2021 - ieeexplore.ieee.org
… We are not discovering proof about further developed … determines specificity of recognition
for HIV-1 protease: analysis of … specificity of HIV-1 protease: an overview. Expert Rev. Mol. …

[HTML][HTML] Effectively predicting HIV-1 protease cleavage sites by using an ensemble learning approach

L Hu, Z Li, Z Tang, C Zhao, X Zhou, P Hu - BMC bioinformatics, 2022 - Springer
specific classifiers to predict HIV-1 protease cleavage sites, … datasets collected for HIV-1
protease cleavage site prediction, we … , and then design a rule-based prediction model based on …

The identification of variable-length coevolutionary patterns for predicting HIV-1 protease cleavage sites

Z Li, L Hu - 2020 IEEE international conference on systems …, 2020 - ieeexplore.ieee.org
Specificity rule discovery in hiv-1 protease cleavage site analysis. Computational Biology …
An mlp-based feature subset selection for hiv-1 protease cleavage site analysis. Artificial …

Machine learning‐guided design of potent darunavir analogs targeting HIV1 proteases: A computational approach for antiretroviral drug discovery

H Chuntakaruk, K Boonpalit… - Journal of …, 2024 - Wiley Online Library
… in human immunodeficiency virus type 1 (HIV-1). Due to the lack of … specific mutations 8 in
essential enzymes of the HIV life cycle. HIV-1 protease (HIV-1 PR) plays a vital role in cleaving

… of the population coverage of an HIV-1 vaccine targeting sequences surrounding the viral protease cleavage sites in Gag, Pol, or all 12 protease cleavage sites

M Daniel, B Liang, M Luo - Vaccine, 2021 - Elsevier
… of infection, HIV-1 protease inhibitors have become a … Cleavage by the HIV-1 protease is a
highly specific and tightly … epitopes using iTopia Epitope Discovery System for the eight most …

Binding interface and impact on protease cleavage for an RNA aptamer to HIV-1 reverse transcriptase

PDM Nguyen, J Zheng, TJ Gremminger… - Nucleic acids …, 2020 - academic.oup.com
… of recognition specificity are poorly understood. We investigated the interface between HIV-1
RT … , the aptamer enhanced proteolytic cleavage of precursor p66/p66 by HIV-1 protease, …

Performance Analysis of Deep CNN Assisted Optimized HIV-I Protease Cleavage Site Prediction with Hybridized Technique

N Kaur, W Ghai - … , Computing and Electronics Systems: Proceedings of …, 2021 - Springer
… antagonist of HIV-1 proteases was discovered in 1987. … is employed for HIV-1 protease
cleavage specificity prediction. It … of the results that predicts the specificity, accuracy, sensitivity of …