determine the X-ray crystal structure of a potent neutralizing monoclonal antibody, CV30,
isolated from a patient infected with SARS-CoV-2, in complex with the receptor binding
domain. The structure reveals that CV30 binds to an epitope that overlaps with the human
ACE2 receptor binding motif providing a structural basis for its neutralization. CV30 also
induces shedding of the S1 subunit, indicating an additional mechanism of neutralization. A …