DNA polyplexes of a phosphorylcholine-based zwitterionic polymer for gene delivery

KM Dave, L Han, MA Jackson, L Kadlecik… - … research, 2020 - Springer
… Modulation of structure and surface chemistry have allowed … -MPC copolymers demonstrated
stable DNA condensation and … present study, we utilized PMPC-DB copolymer to form DNA

Phosphorylcholine-Grafted Molecular Bottlebrush–Doxorubicin Conjugates: High Structural Stability, Long Circulation in Blood, and Efficient Anticancer Activity

S Takano, W Islam, K Nakazawa, H Maeda… - …, 2020 - ACS Publications
… We confirmed the lack of structural transition in the PCMB between before … structure of LP
was significantly influenced by DOX conjugation and transformed from a random-coil structure

Mixed polyplex micelles with thermoresponsive and lysine-based zwitterionic shells derived from two poly (vinyl amine)-based block copolymers

R Kanto, R Yonenuma, M Yamamoto, H Furusawa… - Langmuir, 2021 - ACS Publications
… polyplexes showed the characteristic temperature-induced formation of assembled structures
in … In this study, we used novel mixed polyplex micelles from two series of cationic PVAm-…

Recent advances in supramolecular block copolymers for biomedical applications

W Yasen, R Dong, A Aini, X Zhu - Journal of Materials Chemistry B, 2020 - pubs.rsc.org
… This work provided a novel strategy for achieving both … The condensation capacity of
the resulting SBC for plasmid DNA … degradation and zwitterionic phosphorylcholine based

Photoassisted Surface Modification with Zwitterionic Phosphorylcholine Polymers for the Fabrication of Ideal Biointerfaces

Y Iwasaki - Langmuir, 2023 - ACS Publications
studies on phospholipid adsorption on MPC copolymers with … molecule–induced unfolding
of the hairpin structure. Cationic … on a photolabile linker through condensation. UV (365 nm) …

Recent advances in formulation and application of molecular polymer brushes in biomedicine: Therapeutic, diagnostic, and theranostics capabilities

F Adeli, F Abbasi, P Ghandforoushan, HE Külahlı… - Nano Today, 2023 - Elsevier
… polymer assisted compaction of DNA … of MPBs and their application in novel DDSs, along
with examples of … , so that the amphiphilic graft copolymer with shorter PCL side chains …

Zwitterionic materials for nucleic acid delivery and therapeutic applications

S He, S Liu - Journal of Controlled Release, 2024 - Elsevier
… However, some novel zwitterionic phospholipids have been … To determine the impact of
zwitterionic phosphorylcholine-based … Within the copolymer structure, PCBMA gave a zwitterionic …

Beyond Lipids: Exploring Advances in Polymeric Gene Delivery in the Lipid Nanoparticles Era

CM Jogdeo, K Siddhanta, A Das, L Ding… - Advanced …, 2024 - Wiley Online Library
… creates opportunities for the discovery of novel materials with desirable properties that are
… cationic group condense nucleic acids to form structures called micelleplexes. Studies from …

The complexing of cationic copolymer MPC30-DEA70 with TGF-β1 antisense oligodeoxynucleotide and transfection into cardiomyocytes in vitro

GA Agyekum, M Zhang, F Li, M Sun… - Journal of …, 2023 - journals.sagepub.com
… diblock copolymer, whose highlight is the main structuralcopolymers is found to decrease
the DNA condensation … effects, we can design novel therapeutic strategies to prevent and …

Non‐linear functional polymers containing selective/cleavable bonds: Synthesis and their biomedical applications

M Rahimi, M Gałęziewska, K Jerczyński… - Polymers for …, 2024 - Wiley Online Library
… Researchers fabricated a novel phosphorylcholine-based … multicomponent bottlebrush
copolymers to create structurally and … The formed structures were able to condense plasmid DNA (…