5-Nitroindazole-based compounds: further studies for activity optimization as anti-Trypanosoma cruzi agents

C Fonseca-Berzal, A Ibáñez-Escribano, S de Castro… - Acta Tropica, 2022 - Elsevier
… , a new series of eleven 5-nitroindazole derivatives (10−20) and a related 6-nitroquinazoline
(21) was synthesized and … Among these compounds, derivatives 11−14 and 17 showed …

Antileishmanial activity of 5-nitroindazole derivatives

N Mollineda-Diogo… - Therapeutic …, 2023 - journals.sagepub.com
Derivatives of 5-nitroindazole have shown various biological and pharmacological activities
such as antiprotozoal activity. The study of the activity of indazole against trypanosomatids …

Activity profile of two 5-nitroindazole derivatives over the moderately drug-resistant Trypanosoma cruzi Y strain (DTU TcII): in vitro and in vivo studies

C Fonseca-Berzal, CF da Silva, DGJ Batista… - Parasitology, 2020 - cambridge.org
… among several families of 5-nitroindazole derivatives. The most … Among them, 2-benzyl
derivatives were identified as the best … 5-nitroindazole derivatives were subsequently synthesized

[HTML][HTML] 5-Nitroindazole derivatives as potential therapeutic alternatives against Acanthamoeba castellanii

R Martín-Escolano, G Pérez-Cordón, VJ Arán, C Marín… - Acta Tropica, 2022 - Elsevier
… Our results showed the effectiveness of the 5-nitroindazole derivatives tested … 5-nitroindazole
derivatives against A. castellanii trophozoites and cysts, comparing the activity of these new

[HTML][HTML] Promising hit compounds against resistant trichomoniasis: Synthesis and antiparasitic activity of 3-(ω-aminoalkoxy)-1-benzyl-5-nitroindazoles

A Ibáñez-Escribano, F Reviriego, N Vela… - Bioorganic & Medicinal …, 2021 - Elsevier
… In this sense, our research group has synthesized and tested a large number of …
Additionally, other 5-nitroindazole derivatives such as 1-substituted indazol-3-ols,19, 20 2-…

[HTML][HTML] Using 5-Nitroimidazole Derivatives against Neglected Tropical Protozoan Diseases: Systematic Review

MM Vichi-Ramírez, E López-López… - Future …, 2024 - mdpi.com
new drug candidates that are capable of combating these kinds of diseases. This systematic
review shows that 5-nitroimidazole derivatives … Some nitroimidazole derivatives have been …

Docking Investigation on Bis (Nitro Indazolyl) Methanes; Synthesis and Antimicrobial Activity Towards Breast Cancer Applications

S Jagadeesan, S Karpagam - Letters in Organic Chemistry, 2022 - ingentaconnect.com
… to synthesize Bis (5-nitroindazolyl)methane by electrophilic condensation of 5-nitroindazole
MIC of the derivatives of bis(5-nitroindazole)methanes was performed by the modified agar …

Recent development of heterocyclic compounds with indazole moiety as potential antiparasitic agents

A Paul, T Guria, P Roy, A Maity - Current Topics in Medicinal …, 2022 - ingentaconnect.com
… another eight new 5nitroindazole derivatives for their antichagasic properties. Among all …
[53] developed a new series of 5nitroindazole derivatives with anti-fungal and antibacterial …

Synthesis, Antiviral, Antibacterial, and Cytotoxicity Assessment of Some 3H-Benzo[a]imidazo[4,5-j]acridines and 3H-Benzo[a]pyrazolo[3,4-j]acridines

M Faramarzi, M Pordel, A Morsali - Russian Journal of Organic Chemistry, 2020 - Springer
derivatives have recently received increasing attention due to their biological properties. …
4a–4e were synthesized by the reaction of 5-nitroindazole with various alkyl halides in DMF …

[HTML][HTML] Optimized synthesis of new thiosemicarbazide derivatives with tuberculostatic activity

C Popovici, CM Pavel, V Sunel, C Cheptea… - International Journal of …, 2021 - mdpi.com
… The aim of the study is the increase of new thiosemicarbazide derivatives’ applicative potential
in the field of biochemistry, with a wide range of medical applications. The newly obtained …